CAS 26833-87-4
:Homoharringtonine
Description:
Homoharringtonine, with the CAS number 26833-87-4, is a natural alkaloid derived from the plant species Cephalotaxus harringtonia. It is primarily known for its role as an antineoplastic agent, particularly in the treatment of certain types of leukemia, such as acute myeloid leukemia (AML). The compound functions by inhibiting protein synthesis, which ultimately leads to the suppression of cancer cell proliferation. Homoharringtonine exhibits a unique mechanism of action by targeting the eukaryotic translation initiation process, making it distinct from other chemotherapeutic agents. It is typically administered intravenously and has been studied for its efficacy in combination with other chemotherapy drugs. The substance is characterized by its complex molecular structure, which includes multiple chiral centers, contributing to its biological activity. While it shows promise in clinical applications, its use may be associated with side effects, including myelosuppression and gastrointestinal disturbances. Ongoing research continues to explore its potential and optimize its therapeutic use in oncology.
Formula:C29H39NO9
InChI:InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChI key:InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N
SMILES:O(C([C@@](CCCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]
Synonyms:- (4alpha)-O~3~-[2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
- 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
- Brn 5687925
- Ceflatonin
- Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]
- Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
- Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI)
- Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI)
- Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
- Cgx-635
- Myelostat
- Nsc 141633
- Omacetaxine mepesuccinate
- Omacetaxine mepesuccinate [USAN]
- Omapro
- O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
- Synribo
- Unii-6Fg8041S5B
- See more synonyms
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Homoharringtonine
CAS:Formula:C29H39NO9Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:545.63Omacetaxine Mepesuccinate (Homoharringtonine)
CAS:Formula:C29H39NO9Color and Shape:White To Off-White SolidMolecular weight:545.63Homoharringtonine
CAS:HomoharringtonineFormula:C29H39NO9Purity:99.5%Color and Shape:SolidMolecular weight:545.62Homoharringtonine
CAS:Formula:C29H39NO9Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:545.62Homoharringtonine
CAS:Controlled ProductApplications Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of α-ketoester harringtonine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baaske, D., et al.: Antimicrob. Agents Chemother., 12, 298 (1977), Tipping, A., et al.: Leukemia, 16, 2349 (2002), Marin, D., et al.: Cancer, 103, 1850 (2005), Levy, V., et al.: Br. J. Cancer, 95, 253 (2006), de Lavallade, H., et al.: Blood, 2779 (2007),Formula:C29H39NO9Color and Shape:NeatMolecular weight:545.62Homoharringtonine
CAS:Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.Formula:C29H39NO9Purity:98.21% - 99.96%Color and Shape:White SolidMolecular weight:545.62Homoharringtonine
CAS:Natural alkaloidFormula:C29H39NO9Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:545.63Homoharringtonine - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C29H39NO9Purity:Min. 95%Color and Shape:PowderMolecular weight:545.62 g/molHomoharringtonine
CAS:Homoharringtonine is an alkaloid isolated as an anticancer agent, which is derived from the Cephalotaxus genus of evergreen trees and shrubs. It is specifically extracted from the leaves and bark, traditionally known for its therapeutic applications in Chinese medicine. The mode of action of Homoharringtonine involves the inhibition of protein synthesis. It achieves this by binding to the A-site of the ribosomal subunit, impeding the elongation phase of protein synthesis and thus disrupting cellular proliferation.Formula:C29H39NO9Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:545.62 g/mol
