CAS 269055-15-4

Etravirine

Description:

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used primarily in the treatment of HIV-1 infection. It is characterized by its ability to inhibit the reverse transcriptase enzyme, which is crucial for the replication of the virus. Etravirine is known for its broad activity against various HIV strains, including those resistant to other NNRTIs, making it a valuable option in antiretroviral therapy. The compound has a complex chemical structure, which contributes to its unique pharmacological properties. It is typically administered orally and is often used in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance development. Etravirine is metabolized primarily by the liver, involving cytochrome P450 enzymes, which can lead to drug interactions with other medications. Common side effects may include rash, nausea, and fatigue, but it is generally well-tolerated. Overall, Etravirine represents an important advancement in HIV treatment, particularly for patients with treatment-experienced infections.

Formula: C₂₀H₁₅BrN₆O

InChI: InChI=1/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)

InChI key: InChIKey=PYGWGZALEOIKDF-UHFFFAOYSA-N

SMILES: O(C1=NC(NC2=CC=C(C#N)C=C2)=NC(N)=C1Br)C3=C(C)C=C(C#N)C=C3C

Synonyms:

• 4-((6-Amino-5-Bromo-2-((4-Cyanophenyl)Amino)-4-Pyrimidinyl)Oxy)-3,5-Dimethyl-Benzonitrile
• 4-(6-Amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile
• 4-({6-Amino-5-Bromo-2-[(4-Cyanophenyl)Amino]Pyrimidin-4-Yl}Oxy)-3,5-Dimethylbenzonitrile
• 4-({6-Amino-5-brom-2-[(4-cyanphenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzolcarbonitril
• 4-[[6-Amino-5-Bromo-2-[(4-Cyanophenyl)Amino]-4-Pyrimidinyl]Oxy]-3,5�CDimethylbenzonitrile
• 4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile
• 6-Amino-5-Bromo-4-(4-Cyano-2,6-Dimethylphenoxy)-2-(4-Cyanophenylamino)Pyrimidine
• Benzonitrile, 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-
• Etravirine [INN]
• Etravirine [USAN:INN]
• Intelence
• R 165335
• R165335-Tmc125
• Tmc 125
• Tmc125
• Unii-0C50Hw4Fo1
• Etravirine
• 4-(6-amino-5-bromo-2-(4-cyanobenzyl)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, Etravirine
• 4-[[6-aMino-5-broMo-2-[(4-cyanophenyl)aMino]-4-pyriMidinyl]oxy]-3, 5 –diMethylbenzonitrile/Etravirine
• 4-[[6-AMino-5-broMo-2-[(4-cyanophenyl)aMino]-4-pyriMidinyl]oxy]-3,5-diMethyl
• Etravirine（TMC-125）

ETRAVIRINE CRS

CAS: 269055-15-4

ETRAVIRINE CRS

Ref: 41-Y0002455

Etravirine

CAS: 269055-15-4

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₀H₁₅BrN₆O

Color and Shape: White Off-White Powder

Molecular weight: 434.04907

Ref: 45-1266824

benzonitrile,4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-

CAS: 269055-15-4

Formula: C₂₀H₁₅BrN₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 435.2767

Ref: IN-DA00ILM5

Etravirine

CAS: 269055-15-4

Etravirine

Formula: C₂₀H₁₅BrN₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 435.28

Ref: 54-OR1027791

Etravirine-d6

CAS: 269055-15-4

Formula: C₂₀H₉D₆BrN₆O

Color and Shape: White To Off-White Solid

Molecular weight: 441.32

Ref: 4Z-E-222

Etravirine

CAS: 269055-15-4

Formula: C₂₀H₁₅BrN₆O

Color and Shape: White To Off-White Solid

Molecular weight: 435.29

Ref: 4Z-E-221

Etravirine

CAS: 269055-15-4

Etravirine

Formula: C₂₀H₁₅BrN₆O

Purity: ≥95%

Molecular weight: 435.28

Ref: 54-BUP15329

Etravirine

CAS: 269055-15-4

Formula: C₂₀H₁₅BrN₆O

Molecular weight: 435.28

Ref: 7W-GP8296

Etravirine

CAS: 269055-15-4

Formula: C₂₀H₁₅BrN₆O

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 435.29

Ref: 3B-E1528

Etravirine

CAS: 269055-15-4

Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.

Formula: C₂₀H₁₅BrN₆O

Purity: 97.61% - 99.74%

Color and Shape: White To Off-White Solid

Molecular weight: 435.28

Ref: TM-T2551

Etravirine-d4

CAS: 269055-15-4

Formula: C₂₀H₁₁BrN₆OD₄

Molecular weight: 439.35

Ref: 4Z-E-223

Etravirine

Controlled Product

CAS: 269055-15-4

Applications Etravirine is a novel HIV reverse transcriptase inhibitor useful in treatment of HIV infection.
References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),

Formula: C₂₀H₁₅BrN₆O

Color and Shape: Neat

Molecular weight: 435.28

Ref: TR-E937000

Etravirine

CAS: 269055-15-4

Anti-viral; non-nucleoside reverse transcriptase inhibitor

Formula: C₂₀H₁₅BrN₆O

Purity: Min. 98 Area-%

Color and Shape: White Yellow Powder

Molecular weight: 435.28 g/mol

Ref: 3D-FA16346

Etravirine - Bio-X ™

CAS: 269055-15-4

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) medication used in the treatment of human immunodeficiency virus (HIV) infections. It works by blocking reverse transcriptase, an enzyme essential for replication of the virus, thereby preventing the virus from multiplying and spreading. Etravirine is often used in combination with other antiretroviral drugs to effectively treat HIV/AIDS. It is commonly prescribed for patients with virus strains that are resistant to other NNRTI medications due to mutations that confer resistance- mutations K103N and Y181C. Etravirine is a diarylpyrimidine (DAPY) and has conformational isomerism meaning that it binds reverse transcriptase in an fleible manner, under multiple conformations. The impact of specific point mutations in the virus is therefore lessened.

Formula: C₂₀H₁₅BrN₆O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 435.28 g/mol

Ref: 3D-BA164437

ETRAVIRINE

CAS: 269055-15-4

Purity: ≥95%

Molecular weight: 435.2850037

Ref: 10-F856916

Etravirine

CAS: 269055-15-4

Formula: C₂₀H₁₅BrN₆O

Molecular weight: 435.3

Ref: ST-EA-CP-E23000