CAS 26934-87-2

HT 2 Toxin

Description:

HT 2 Toxin, with the CAS number 26934-87-2, is a mycotoxin produced by certain species of fungi, particularly those belonging to the genus Fusarium. It is primarily associated with contaminated grains and can pose significant health risks to both humans and animals. The toxin is known for its potential to cause various toxicological effects, including immunosuppression and reproductive issues. HT 2 Toxin is classified as a type A trichothecene, which is characterized by its ability to inhibit protein synthesis in cells, leading to cytotoxic effects. Its chemical structure features a complex arrangement of rings and functional groups that contribute to its biological activity. Due to its toxicity, regulatory agencies monitor its levels in food and feed products to ensure safety. Proper handling and testing are essential to mitigate exposure risks, especially in agricultural contexts where contaminated crops may be present. Overall, HT 2 Toxin is a significant concern in food safety and public health.

Formula: C₂₂H₃₂O₈

InChI: InChI=1/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20+,21+,22+/m0/s1

InChI key: InChIKey=PNKLMTPXERFKEN-MLXHEQMXSA-N

SMILES: C[C@]12[C@@]3([C@](O[C@]4([C@]1(COC(C)=O)C[C@H](OC(CC(C)C)=O)C(C)=C4)[H])([C@H](O)[C@H]2O)[H])CO3

Synonyms:

• (2alpha,3beta,4alpha,5alpha,6beta,8beta,11beta,12R)-15-(acetyloxy)-3,4-dihydroxy-12,13-epoxytrichothec-9-en-8-yl 3-methylbutanoate
• (3beta,4alpha,8alpha,12R)-15-(acetyloxy)-3,4-dihydroxy-12,13-epoxytrichothec-9-en-8-yl 3-methylbutanoate
• 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 15-acetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
• 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 15-acetate 8-isovalerate
• 15-Acetoxy-3,4-dihydroxy-8-(3-methylbutyryloxy)-12,13-epoxy delta9-trichothecene
• 3,4-Dihydroxy-15-acetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-Δ⁹-trichothecene
• HT 2 mycotoxin
• Ht-2
• Isovaleric acid, 8-ester with 12,13-epoxytrichothec-9-ene-3α,4β,8α,15-tetrol 15-acetate
• Mycotoxin HT 2
• Nsc 278571
• Spiro[2,5-methano-1-benzoxepin-10,2′-oxirane], trichothec-9-ene-3,4,8,15-tetrol deriv.
• Toxin HT 2
• Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15 acetate 8-(3-methylbutanoate), (3alpha,4abeta,8alpha)- (9CI)
• Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15-acetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)- (9CI)
• Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15-acetate 8-(3-methylbutanoate), (3α,4β,8α)-
• Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 15-acetate, 8-isovalerate
• Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 15-acetate 8-isovalerate (8CI)
• Trichothec-9-ene-3α,4β,8α,15-tetrol, 12,13-epoxy-, 15-acetate 8-isovalerate
• HT 2 Toxin
• 3,4-Dihydroxy-15-acetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-Δ9-trichothecene
• (3alpha,4beta,8alpha)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 15-acetate 8-(3-methylbutanoate)
• mycotoxinht2
• T-2, Toxin analog
• HT-2 toxin, FroM FusariuM sp.
• 15-Acetoxy-3alpha-4beta-dihydoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
• HT-2 Toxin (3alpha,4beta,8alpha)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 15-acetate 8-(3-methylbutanoate)
• 12,13-Epoxytrichothec-9-ene-3α,4β,8α,15-tetrol 15-acetate 8-(3-methylbutanoate)
• 12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol15-acetate8-iso
• 4-beta,8-alpha,15-tetrol,12,13-epoxy-,15-acetate,8-trichothec-9-ene-3-alph
• HT-2 toxin 100ug/ml in ACN
• 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-8ALPHA-[3-METHYLBUTYRYLOXY]-12,13-EPOXYTRICHOTHEC-9-ENE
• HT-2 toxin, 99%, from Fusarium sp.
• Trichothen-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15-acetate 8-(3-methylbutanoate)
• U-[13C22]-HT-2 Toxin Solution, 25μg/mL
• Pentanoic acid anion
• (3α,4β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 8-(3-Methylbutanoate) 15-Acetate
• 12,13-Epoxytrichothec-9-ene-3α,4β,8α,15-tetro 15-Acetate 8-Isovalerate
• valerate
• ht-2toxin solution
• 15-acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
• HT-2 toxin,15-Acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
• Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 15-acetate 8-isovalerate
• Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 15-acetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-

HT-2 toxin

Controlled Product

CAS: 26934-87-2

HT-2 toxin

Formula: C₂₂H₃₂O₈

Purity: 99% (tlc) (Typical Value in Batch COA)

Color and Shape: Solid

Molecular weight: 424.49

Ref: 54-BIH1001

HT-2 Toxin 100 µg/mL in Acetonitrile

Controlled Product

CAS: 26934-87-2

Formula: C₂₂H₃₂O₈

Color and Shape: Single Solution

Molecular weight: 424.48

Ref: 04-A14214000AL-100

A + B-Trichothecenes and Zearalenone Mixture 10 µg/mL in Acetonitrile

Controlled Product

CAS: 17924-92-4, 21259-20-1, 2270-40-8, 23255-69-8, 23282-20-4, 26934-87-2, 50722-38-8, 51481-10-8, 5975-78-0

Color and Shape: Mixture

Ref: 04-V30000004AL

HT-2 Toxin 100 µg/mL in Acetonitrile

Controlled Product

CAS: 26934-87-2

Formula: C₂₂H₃₂O₈

Color and Shape: Single Solution

Molecular weight: 424.48

Ref: 04-V14214000AL-100

Fusarium Toxins Mixture 10-100 µg/mL in Acetonitrile

Controlled Product

CAS: 17924-92-4, 21259-20-1, 26934-87-2, 51481-10-8, 5975-78-0

Color and Shape: Mixture

Ref: 04-V30000007AL

A + B-Trichothecenes and Zearalenone Mixture 10 µg/mL in Acetonitrile

Controlled Product

CAS: 17924-92-4, 21259-20-1, 2270-40-8, 23255-69-8, 23282-20-4, 26934-87-2, 50722-38-8, 51481-10-8

Color and Shape: Mixture

Ref: 04-A30000004AL

HT-2 Toxin

Controlled Product

CAS: 26934-87-2

Formula: C₂₂H₃₂O₈

Molecular weight: 424.49

Ref: 4Z-M-214004

HT-2 Toxin (>85%)

Controlled Product

CAS: 26934-87-2

Stability Hygroscopic
Applications HT-2 Toxin is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin (T002980) which has been shown to induce DNA damage and cell death on prolonged administration.Environmental contaminants; Food contaminants
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Weidner, M. et al.: J. Agric. Food Chem., 60, 5676 (2012); Choi, H. et al.: Toxicol. Appl. Pharmacol., 240, 46 (2009); Amuzie, C. et al.: Toxicol. Sci., 113, 412 (2010);

Formula: C₂₂H₃₂O₈

Purity: >85%

Color and Shape: Neat

Molecular weight: 424.48

Ref: TR-H671800

HT-2 Toxin

Controlled Product

CAS: 26934-87-2

HT-2 Toxin is a toxin that is produced by the bacteria Clostridium botulinum. The HT-2 toxin is used as an analytical method to determine the concentration of this toxin in food, and as a research tool for studying the effects of toxins on cell membrane potential. HT-2 Toxin binds to the mitochondria of cells and causes a loss in mitochondrial membrane potential, which leads to cell death. The HT-2 toxin has been shown to be inhibitory at doses below those that would lead to full lethality. It is also highly sensitive to glycosidic bonds, which are found in many foods, such as malonic acid and zearalenone. These two compounds have been shown to be inhibitors of glycosidase enzymes, which may play a role in the detoxification process. The HT-2 toxin can also induce autophagy in cells that are resistant to its toxic effects.

Formula: C₂₂H₃₂O₈

Purity: Min. 95%

Molecular weight: 424.49 g/mol

Ref: 3D-BH162733

HT-2 Toxin-13C-d3

Controlled Product

CAS: 26934-87-2

Formula: C₂₁₁₃CH₂₉D₃O₈

Molecular weight: 428.50

Ref: 4Z-M-214006

HT-2 Toxin-d3

Controlled Product

CAS: 26934-87-2

Formula: C₂₂H₂₉D₃O₈

Molecular weight: 427.51

Ref: 4Z-M-214005