CAS 27060-91-9

Flutazolam

Description:

Flutazolam is a chemical compound classified as a benzodiazepine derivative, primarily known for its sedative and anxiolytic properties. It is characterized by its ability to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibitory neurotransmission in the central nervous system. This mechanism of action contributes to its use in managing anxiety, insomnia, and other related disorders. Flutazolam typically exhibits a rapid onset of action and a relatively short half-life, making it effective for acute treatment scenarios. However, like other benzodiazepines, it carries a risk of dependence, tolerance, and withdrawal symptoms with prolonged use. Its pharmacokinetic profile, including absorption, distribution, metabolism, and excretion, is influenced by various factors, including individual patient characteristics and concurrent medications. Due to its potential for abuse and the associated side effects, flutazolam is subject to regulatory controls in many countries. As with any medication, it is essential to use flutazolam under the guidance of a qualified healthcare professional.

Formula: C₁₉H₁₈ClFN₂O₃

InChI: InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2

InChI key: InChIKey=WMFSSTNVXWNLKI-UHFFFAOYSA-N

SMILES: FC1=C(C23C=4C(N(CCO)C(=O)CN2CCO3)=CC=C(Cl)C4)C=CC=C1

Synonyms:

• 10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
• 10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
• 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
• Brn 1092501
• Coreminal
• Flutazolam [INN:JAN]
• Flutazolamum
• Flutazolamum [INN-Latin]
• Ms-4101
• Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-
• Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-
• Ro 7-6102
• Unii-5G2K7O5D8S

Flutazolam

Controlled Product

CAS: 27060-91-9

Applications Flutazolam can be used as analyte in analytical study of development and application of a multi-component LC-MS/MS method for determination of designer benzodiazepines in urine. A benzodiazepine derivative that has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects.
References Pettersson B., et al.: J Chromatgr B, 1035, 104 (2016)

Formula: C₁₉H₁₈ClFN₂O₃

Color and Shape: Neat

Molecular weight: 376.81

Ref: TR-F599405

Flutazolam

Controlled Product

CAS: 27060-91-9

Flutazolam is an analog of the benzodiazepine class of drugs, which are used as sedatives, hypnotics, and anticonvulsants. Flutazolam binds to the GABAA receptor and inhibits locomotor activity in rats. This drug has been shown to have a beneficial effect on bowel disease by reducing inflammation and improving symptoms such as abdominal pain and diarrhea. Flutazolam is also used for the treatment of nocturnal enuresis (bedwetting) in children. Flutazolam is metabolized into polymeric matrixes that are excreted through urine samples. These polymeric matrixes are fatty esters that are formed from a reaction between flutazolam and sodium citrate, human serum albumin, or fatty acids. The chemical ionization mass spectrometry profile of flutazolam is characterized by two major peaks at m/z 193 and m/z 195 which correspond to the molecular

Formula: C₁₉H₁₈ClFN₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 376.8 g/mol

Ref: 3D-CBA06091