CAS 2715104-45-1

PROTAC HMGCR Degrader-1

CAS: 2715104-45-1

PROTACHMGCR Degrader-1 is an orally active HMGCRPROTAC degrader with an IC50 of 1.32 μM. It is a lactone prodrug derived from PROTACHMGCR Degrader-2. In vivo, PROTACHMGCR Degrader-1 achieves high plasma exposure of the active compound, leading to potent HMGCR degradation and demonstrating effective cholesterol-lowering properties. This compound is applicable for research related to hyperlipidemia.

Formula: C₅₃H₇₇N₅O₉S

Molecular weight: 960.29

Ref: TM-T217132