CAS 27164-46-1

Cefazolin sodium

Description:

Cefazolin sodium is a first-generation cephalosporin antibiotic, primarily used for the treatment of bacterial infections. It is effective against a variety of gram-positive bacteria and some gram-negative organisms. The compound is characterized by its beta-lactam structure, which is essential for its antibacterial activity. Cefazolin is typically administered via injection, as it is not well absorbed when taken orally. It has a relatively long half-life, allowing for less frequent dosing compared to some other antibiotics. The sodium salt form enhances its solubility in water, making it suitable for intravenous or intramuscular administration. Common indications for cefazolin include surgical prophylaxis and the treatment of skin, bone, and joint infections. While generally well-tolerated, it can cause side effects such as allergic reactions, gastrointestinal disturbances, and, in rare cases, nephrotoxicity. As with all antibiotics, it is crucial to use cefazolin judiciously to prevent the development of antibiotic resistance.

Formula: C₁₄H₁₃N₈NaO₄S₃

InChI: InChI=1/C14H14N8O4S3.Na/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21;/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26);/q;+1/p-1/t9-,12-;/m1./s1

InChI key: InChIKey=BXZNAOVMWGRSJT-WYUVZMMLSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CN3C=NN=N3)=O)C2=O)(SCC1CSC=4SC(C)=NN4)[H].[Na]

Synonyms:

• 3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-7-[2-(1H-tetrazol-1-yl)-acetamido]-3-cephem-4-carboxylic acid sodium salt
• 3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, monosodium salt, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, monosodium salt, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-, monosodium salt
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-, sodium salt (1:1), (6R,7R)-
• Ancef
• Atirin
• Azolin
• Biazolina
• Bor-Cefazol
• Cefacidal
• Cefamedin
• Cefazil
• Cefazina
• Cefazoliin
• Cefazolin Sodium
• Cefazoline sodium
• Cefazorin DC
• Cephazolin sodium
• Cephazolin sodium salt
• Firmacef
• Gramaxin
• Iespor
• Kefzol
• Lampocef
• Liviclina
• Monosodium cafazolin
• NSC 291561
• Reflin
• Skf 41558
• Sodium CEZ
• Sodium cefazolin
• Sodium cephazolin
• Totacef
• Zolicef
• sodium (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• sodium 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Cefazolin, Sodium Salt
• sodiumcefazolin
• sodiumcephazolin
• CEFAZOLIN NA
• (6r-trans
• sodiumcez
• cezsodium

Cefazolin Sodium

CAS: 27164-46-1

Formula: C₁₄H₁₃N₈NaO₄S₃

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 476.48

Ref: 10-F036519

7-epi-Cefazolin Sodium Salt

Controlled Product

CAS: 27164-46-1

Formula: C₁₄H₁₃N₈O₄S₃·Na

Color and Shape: Neat

Molecular weight: 476.49

Ref: TR-C242510

Cefazolin Sodium

CAS: 27164-46-1

Formula: C₁₄H₁₃N₈NaO₄S₃

Molecular weight: 476.48

Ref: ST-EA-CP-C149020