CAS 27220-47-9: Econazole
Description:Econazole is an antifungal agent belonging to the imidazole class of compounds, primarily used in the treatment of various fungal infections. It exhibits broad-spectrum antifungal activity against dermatophytes, yeasts, and some molds by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to increased membrane permeability and ultimately cell death. Econazole is typically formulated as a topical cream, lotion, or powder for localized application, making it effective for conditions such as athlete's foot, ringworm, and candidiasis. The substance is characterized by its relatively low solubility in water, which enhances its efficacy when applied to the skin. Additionally, it has a moderate lipophilicity, allowing for better penetration through the skin barrier. Econazole is generally well-tolerated, with minimal systemic absorption when used topically, although some local irritation may occur. Its chemical structure includes a 1H-imidazole ring, contributing to its pharmacological properties. Overall, Econazole is a valuable agent in dermatological antifungal therapy.
Formula:C18H15Cl3N2O
InChI:InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
InChI key:InChIKey=LEZWWPYKPKIXLL-UHFFFAOYSA-N
SMILES:ClC1=CC=C(C=C1)COC(C2=CC=C(Cl)C=C2Cl)CN3C=NC=C3
- Synonyms:
- 1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole
- 1-[2,4-Dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]imidazole
- 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
- 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
- 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-
- Brn 0964150
- Ccris 9032
- Econazol
- Econazol [INN-Spanish]
- Econazolum
- See more synonyms
- Ecostatin
- Imidazole, 1,2,4-dichloro-beta-(p-chlorobenzyl)oxyphenethyl-
- Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-
- Imidazole, 1-[2,4-dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]-
- Nsc 187789
- Unii-6Z1Y2V4A7M
- Econazole