CAS 2731294-23-6

1-(4-(4-Amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-3-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)urea

Description:

The chemical substance known as 1-(4-(4-Amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-3-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)urea, with the CAS number 2731294-23-6, is a complex organic compound characterized by its unique structural features. It contains multiple functional groups, including an amino group, a urea moiety, and a trifluoromethyl group, which contribute to its potential biological activity. The presence of the pyrrolo[2,3-d]pyrimidine and isoxazole rings suggests that this compound may exhibit interesting pharmacological properties, possibly acting as a kinase inhibitor or having other therapeutic applications. Its cyclopropyl substituents may enhance lipophilicity and influence its interaction with biological targets. The fluorine atom in the phenyl ring can also affect the compound's electronic properties and metabolic stability. Overall, this compound's intricate structure and diverse functional groups make it a candidate for further investigation in medicinal chemistry and drug development.

Formula: C₂₃H₁₉F₄N₇O₂

Synonyms:

• 1-(4-(4-Amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-3-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)urea
• Urea, N-[4-(4-amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl]-N′-[5-[1-(trifluoromethyl)cyclopropyl]-3-isoxazolyl]-
• Ofirnoflastum (Ofirnoflast)

1-(4-(4-Amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-3-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)urea

CAS: 2731294-23-6

1-(4-(4-Amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-3-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)urea

Formula: C₂₃H₁₉F₄N₇O₂

Purity: 95%

Molecular weight: 501.44

Ref: 54-PC1007093

Ofirnoflastum

CAS: 2731294-23-6

Ofirnoflastum (Ofirnoflast) is a selective serine/threonine-protein kinase Nek7 inhibitor that exerts potent anti-inflammatory effects by suppressing Nek7-dependent NLRP3 inflammasome activation, reducing caspase-1 cleavage, IL-1β and IL-18 secretion, and pyroptotic cell death in vitro, while significantly attenuating cytokine production and tissue injury in animal models of acute and chronic inflammation, supporting its therapeutic potential in autoimmune and inflammatory diseases.

Formula: C₂₃H₁₉F₄N₇O₂

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 501.44

Ref: TM-T201705

Ofirnoflastum

CAS: 2731294-23-6

1-(4-(4-Amino-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-3-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-yl)urea

Formula: C₂₃H₁₉F₄N₇O₂

Purity: 95%

Molecular weight: 501.44

Ref: IN-DG02700511