CAS 27469-60-9

1-Bis(4-fluorophenyl)methyl piperazine

Description:

1-Bis(4-fluorophenyl)methyl piperazine, with the CAS number 27469-60-9, is a chemical compound characterized by its piperazine core, which is a six-membered heterocyclic amine. This compound features two para-fluorophenyl groups attached to a central piperazine ring, contributing to its unique properties. It is typically a solid at room temperature and exhibits moderate solubility in organic solvents, which is influenced by the presence of the fluorine atoms that enhance its lipophilicity. The fluorine substituents can also affect the compound's electronic properties, potentially influencing its reactivity and interaction with biological targets. 1-Bis(4-fluorophenyl)methyl piperazine may be of interest in medicinal chemistry, particularly in the development of pharmaceuticals, due to its structural features that can modulate biological activity. Additionally, its synthesis and characterization involve standard organic chemistry techniques, and it may be studied for its potential applications in various fields, including drug design and material science.

Formula: C₁₇H₁₈F₂N₂

InChI: InChI=1/C17H18F2N2/c18-15-5-1-13(2-6-15)17(21-11-9-20-10-12-21)14-3-7-16(19)8-4-14/h1-8,17,20H,9-12H2/p+2

InChI key: InChIKey=TTXIFFYPVGWLSE-UHFFFAOYSA-N

SMILES: C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)N3CCNCC3

Synonyms:

• 1-(4,4'-Difluorobenzhydryl)Piperazine
• 1-(Di-p-fluorobenzhydryl)piperazine
• 1-[Bis(4-Fluorophenyl)Methyl]Piperazinediium
• 4,4'-Difluorobenzhydrylpiperazine
• 4-[Bis(4-fluorophenyl)methyl]piperazine
• Di(4-fluorophenyl)methyl piperazine
• N-(4,4-Difluorobenzhydryl)piperazine
• N-(Bis(4-fluorophenyl)methyl)piperazine
• Piperazine, 1-[bis(4-fluorophenyl)methyl]-
• Piperazine, 1-[bis(p-fluorophenyl)methyl]-
• R 19352
• T 841
• 1-[Bis(4-fluorophenyl)methyl]piperazine
• 1-[Bis(4-fluorophenyl)methyl]piperazine
• 1-(bis(4-fluorophenyl)methyl) piperazine
• 1-(4,4'-Diflurobenzhydryl)piperazine
• 1-(4,4'-DIFLUORODIPHENYLMETHYL)PIPERAZINE
• 1-(4,4'-Difluorobenzhydryl)piperazine 97%
• 1-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZINE HYDROGEN CHLORIDE
• N-(4,4"-DIFLUOROBENZYLHYDRYL) PIPERAZINE
• 1-BIS (P-FLUOROPHENYL) METHYL PIPERAZINE
• 4,4-Difluorobenzhydrolpiperazine
• 1-[BIS(4-FLUOROPHENZYL)METHYL]PIPERAZINE
• 1-BIS(4-FLUOROPHENYL)METHYL PIPERAZINE 97%
• 1-(4,4'-Difluorobenzhydryl)piperazine97%
• TIMTEC-BB SBB002996
• 1-[DI(4-FLUOROPHENYL)METHYL]PIPERAZINE
• 1-[Bis(4-Fluorophenyl)methyl]p
• 4,4'-DIFLUOROBENZHYDRYL PIPERAZINE

1-[Bis(4-fluorophenyl)methyl]piperazine

CAS: 27469-60-9

Formula: C₁₇H₁₈F₂N₂

Purity: >97.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 288.34

Ref: 3B-B2764

1-Bis(4-fluorophenyl)methyl piperazine

CAS: 27469-60-9

Formula: C₁₇H₁₈F₂N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 288.3350

Ref: IN-DA003KF5

Flunarizine EP Impurity A

CAS: 27469-60-9

Formula: C₁₇H₁₈F₂N₂

Color and Shape: White To Off-White Solid

Molecular weight: 288.34

Ref: 4Z-F-084009

1-[Bis(4-fluorophenyl)methyl]piperazine

CAS: 27469-60-9

1-[Bis(4-fluorophenyl)methyl]piperazine

Formula: C₁₇H₁₈F₂N₂

Purity: 98%

Color and Shape: white to off-white powder

Molecular weight: 288.34g/mol

Ref: 54-PC5636

Flunarizine EP Impurity A

Controlled Product

CAS: 27469-60-9

Formula: C₁₇H₁₈F₂N₂

Color and Shape: White To Light Yellow

Molecular weight: 288.34

Ref: 86-MM0175.04

1-Bis(4-fluorophenyl)methyl Piperazine

Controlled Product

CAS: 27469-60-9

Impurity Flumazenil EP Impurity A
Stability Hygroscopic
Applications 1-Bis(4-fluorophenyl)methyl Piperazine (Flumazenil EP Impurity A) is a chemical reagent used in the synthesis of novel tubulin polymerization inhibitors. Also used in the synthesis of novel benzhydrylpiperazine carboxamide derivatives. Impurity of F455200
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, Y. et al.: Bioorg. Med. Chem., 22, 2409 (2014); Gurdal, E. et al.: J. Enz. Inhib. Med. Chem., 29, 205 (2014);

Formula: C₁₇H₁₈F₂N₂

Color and Shape: White To Light Yellow

Molecular weight: 288.34

Ref: TR-B434875

1-[Bis-(4-fluorophenyl)methyl]piperazine

CAS: 27469-60-9

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 288.3420104980469

Ref: 10-F019234

1-Bis(4-fluorophenyl)methyl Piperazine-d8

Controlled Product

CAS: 27469-60-9

Applications 1-Bis(4-fluorophenyl)methyl Piperzaine-d8 is a labelled analogue of 1-Bis(4-fluorophenyl)methyl Piperzaine (B434875), which is a chemical reagent used in the synthesis of novel tubulin polymerization inhibitors. Also used in the synthesis of novel benzhydrylpiperazine carboxamide derivatives. Impurity of F455200. It is also an intermediate in synthesizing Flunarizine-d8 Dihydrochloride (F455202), which is a calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yin, Y. et al.: Bioorg. Med. Chem., 22, 2409 (2014); Gurdal, E. et al.: J. Enz. Inhib. Med. Chem., 29, 205 (2014); Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975); Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979); Nihard, P., et al.: Angiology, 33, 37 (1982); Holmes, B., et al.: Drugs, 27, 6 (1984);

Formula: C₁₇H₁₀D₈F₂N₂

Color and Shape: Neat

Molecular weight: 296.38

Ref: TR-B434877

Flunarizine EP Impurity A

CAS: 27469-60-9

Formula: C₁₇H₁₈F₂N₂

Molecular weight: 288.34

Ref: ST-EA-CP-F140003

1-(4,4'-Difluorobenzhydry)piperazine

CAS: 27469-60-9

1-(4,4'-Difluorobenzhydry)piperazine (1-DFBP) is a potential antitumor agent that has been shown to inhibit the growth of leukemia cells. It may be an inhibitor of apoptotic cell death, as it has been shown to induce hydrogen bond formation with coumarin derivatives. 1-DFBP has also been shown to have inhibitory activities against leukemia HL-60 cells, and is a competitive inhibitor of cinnarizine. The catalytic mechanism for 1-DFBP is not known, although kinetic data suggest that it involves hydrogen bonding and/or pi stacking interactions.

Formula: C₁₇H₁₈F₂N₂

Purity: Min. 95%

Molecular weight: 288.34 g/mol

Ref: 3D-FD55069