CAS 2748366-80-3

HK2-IN-4

CAS: 2748366-80-3

HK2-IN-4 is a selective hexokinase 2 (HK2) inhibitor with an IC₅₀ value of 0.79 μM and a Kd value of 0.41 μM. It disrupts the interaction between HK2 and the voltage-dependent anion channel 1 (VDAC1). HK2-IN-4 reduces lactate and ATP levels in cancer cells and induces apoptosis markers, including increased p-AMPK/AMPK ratio and Bax levels, along with decreased Bcl2 levels. Additionally, HK2-IN-4 inhibits the proliferation of cancer cells with high HK2 expression and can be utilized in research related to colorectal cancer and non-small cell lung cancer.

Formula: C₂₄H₂₅NO₄

Molecular weight: 391.46

Ref: TM-T218671