CAS 2750895-97-5

MTX115325

Formula: C₁₈H₁₆N₆O₂

InChI: InChI=1S/C18H16N6O2/c1-11-14-3-5-24(15(14)9-23(11)10-20)18(25)17-22-8-16(26-17)12-2-4-21-13(6-12)7-19/h2,4,6,8,11,14-15H,3,5,9H2,1H3/t11-,14-,15+/m1/s1

InChI key: LBHXWJUYDOSAAH-DFBGVHRSSA-N

SMILES: C[C@@H]1[C@H]2CCN([C@H]2CN1C#N)C(=O)C3=NC=C(O3)C4=CC(=NC=C4)C#N

Synonyms:

• MTX115325

MTX115325

CAS: 2750895-97-5

MTX115325

Formula: C₁₈H₁₆N₆O₂

Purity: 95%

Molecular weight: 348.36

Ref: 54-OR1174941

MTX115325

CAS: 2750895-97-5

Purity: 95%

Ref: IN-DA02E6EG

MTX115325

CAS: 2750895-97-5

MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].

Formula: C₁₈H₁₆N₆O₂

Color and Shape: Solid

Molecular weight: 348.36

Ref: TM-T86936