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CAS 2752441-61-3

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    APL-4098

    CAS:
    APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. It reduces the phosphorylation levels of eIF2α and the expression of ATF4. APL-4098 impairs mitochondrial function and exhibits cytotoxicity against primary acute myeloid leukemia cells. It is applicable in studies related to acute myeloid leukemia.
    Formula:C17H12ClFN6O3S
    Molecular weight:434.83

    Ref: TM-T218287

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