CAS 2760446-25-9
:Formula:C29H21FN4O3
InChI:InChI=1S/C29H21FN4O3/c30-22-15-17-23(18-16-22)33(28(36)21-11-5-2-6-12-21)19-26-31-25-14-8-7-13-24(25)29(37)34(26)32-27(35)20-9-3-1-4-10-20/h1-18H,19H2,(H,32,35)
InChI key:BXEOGVYDILYVAK-UHFFFAOYSA-N
SMILES:C1=CC=C(C=C1)C(=O)NN2C(=NC3=CC=CC=C3C2=O)CN(C4=CC=C(C=C4)F)C(=O)C5=CC=CC=C5
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LMDP10
CAS:LMDP10 is an orally active 3-aminoquinazoline derivative that activates the Keap1-Nrf2 pathway. It binds to Keap1, inhibiting the Keap1-Nrf2 interaction and subsequently activating the Nrf2 pathway. This leads to increased levels of Nrf2, SOD, and GSH, while reducing MDA and TNF-α levels. As a result, LMDP10 alleviates neurodegeneration and improves memory in Alzheimer's disease (AD) rat models. LMDP10 is applicable for Alzheimer's disease (AD) research.Formula:C29H21FN4O3Molecular weight:492.51
