CAS 2761881-65-4

P-gp-IN-30

CAS: 2761881-65-4

P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC).

Formula: C₃₄H₃₆N₂O₉

Molecular weight: 616.66

Ref: TM-T211609