CAS 2763268-64-8

Formula: C51H64F2N10O5S

InChI: InChI=1S/C51H64F2N10O5S/c1-32(35-12-14-37(15-13-35)46-33(2)56-31-69-46)57-48(67)40-27-39(64)29-63(40)49(68)47(50(3,4)5)60-44(65)10-8-6-7-9-11-45(66)61-21-17-36(18-22-61)38-25-42(58-41-24-34(28-54)16-20-55-41)59-43(26-38)62-23-19-51(52,53)30-62/h12-16,20,24-26,31-32,36,39-40,47,64H,6-11,17-19,21-23,27,29-30H2,1-5H3,(H,57,67)(H,60,65)(H,55,58,59)/t32-,39+,40-,47+/m0/s1

InChI key: NNOXSMGLIYXSCU-OMSCPKDKSA-N

SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCC(=O)N4CCC(CC4)C5=CC(=NC(=C5)N6CCC(C6)(F)F)NC7=NC=CC(=C7)C#N)O

PROTAC LZK-IN-1

CAS: 2763268-64-8

PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.

Formula: C₅₁H₆₄F₂N₁₀O₅S

Color and Shape: Solid

Molecular weight: 967.18

Ref: TM-T204373