CAS 27833-64-3
:Loxapine succinate
Description:
Loxapine succinate is a pharmaceutical compound primarily used as an antipsychotic medication. It is a derivative of loxapine, which belongs to the class of typical antipsychotics. The substance is characterized by its ability to antagonize dopamine receptors, particularly D2 receptors, which plays a crucial role in its therapeutic effects in managing schizophrenia and other psychotic disorders. Loxapine succinate is typically administered in its succinate salt form, enhancing its solubility and bioavailability. The compound exhibits a moderate side effect profile, which may include sedation, extrapyramidal symptoms, and anticholinergic effects. Its pharmacokinetics involve hepatic metabolism, and it is primarily excreted through urine. The chemical structure includes a dibenzodiazepine core, contributing to its pharmacological activity. As with any medication, the use of loxapine succinate should be closely monitored by healthcare professionals to manage potential side effects and interactions with other medications. Overall, loxapine succinate is an important option in the treatment of certain psychiatric conditions, reflecting its role in modern psychopharmacology.
Formula:C18H18ClN3O·C4H6O4
InChI:InChI=1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
InChI key:InChIKey=YQZBAXDVDZTKEQ-UHFFFAOYSA-N
SMILES:ClC=1C=C2C(=NC=3C(OC2=CC1)=CC=CC3)N4CCN(C)CC4.C(CC(O)=O)C(O)=O
Synonyms:- 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz[b,f][1,4]oxazepine succinate
- Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine (1:1)
- Cl 71563
- Daxolin
- Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, butanedioate (1:1)
- Loxapac
- Loxapine Succinate
- Loxapine Succinate Salt
- Loxitane
- Loxitane Capsules
- Succinic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine (1:1)
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Found 14 products.
Loxapine Succinate
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C18H18ClN3O·C4H6O4Color and Shape:White Yellow PowderMolecular weight:445.140452-Chloro-11-(4-methyl-1-piperazinyl)-dibenz[b,f][1,4]oxazepine succinate
CAS:Formula:C22H24ClN3O5Purity:98%Color and Shape:SolidMolecular weight:445.8961Loxapine succinate
CAS:Loxapine succinate (Loxapac), a D2DR and D4DR inhibitor, is utilized in schizophrenia.Formula:C22H24ClN3O5Purity:99.69%Color and Shape:White SolidMolecular weight:445.9Loxapine succinate salt
CAS:Formula:C18H18ClN3O·C4H6O4Purity:≥ 98.0% (dried basis)Color and Shape:White to off-white powderMolecular weight:445.90Loxapine succinate salt
CAS:Loxapine succinate saltFormula:C18H18ClN3O·C4H6O4Purity:≥99%Color and Shape:SolidMolecular weight:445.89605Loxapine Succinate
CAS:Controlled ProductFormula:C18H18ClN3O·C4H6O4Color and Shape:NeatMolecular weight:445.90Loxapine, Succinate
CAS:Controlled ProductApplications A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent.
References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)Formula:C18H18ClN3O·C4H6O4Color and Shape:NeatMolecular weight:445.9Loxapine succinate
CAS:Controlled ProductAntagonist of dopamine (D2/D4), histamine and serotonin receptorsFormula:C18H18ClN3O·C4H6O4Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:445.9 g/molButanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine (1:1)
CAS:Purity:≥99%Molecular weight:445.8999939
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