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CAS 2799-15-7

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D-α-Methyldopa

Description:
D-α-Methyldopa, with the CAS number 2799-15-7, is an antihypertensive medication primarily used to treat high blood pressure. It is a centrally acting alpha-2 adrenergic agonist, which means it works by stimulating alpha-2 receptors in the brain, leading to a decrease in sympathetic outflow and a subsequent reduction in blood pressure. The chemical structure of D-α-Methyldopa includes a phenylalanine derivative, characterized by a carboxylic acid group and an amino group, making it a zwitterionic compound at physiological pH. It is typically administered in its salt form, often as methyldopa hydrochloride. D-α-Methyldopa is known for its relatively favorable side effect profile, particularly in pregnant women, where it is considered safe for managing hypertension. Common side effects may include sedation, dry mouth, and potential liver function alterations. Its pharmacokinetics involve conversion to alpha-methyl norepinephrine, which contributes to its antihypertensive effects. Overall, D-α-Methyldopa remains an important therapeutic option in the management of hypertension, especially in specific patient populations.
Formula:C10H13NO4
InChI:InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m1/s1
InChI key:InChIKey=CJCSPKMFHVPWAR-SNVBAGLBSA-N
SMILES:C([C@@](C(O)=O)(C)N)C1=CC(O)=C(O)C=C1
Synonyms:
  • (+)-a-Methyldopa
  • (2R)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
  • 3-Hydroxy-α-methyl-<span class="text-smallcaps">D</span>-tyrosine
  • <span class="text-smallcaps">D</span>-(3,4-Dihydroxyphenyl)-2-methylalanine
  • <span class="text-smallcaps">D</span>-Methyldopa
  • <span class="text-smallcaps">D</span>-Tyrosine, 3-hydroxy-α-methyl-
  • <span class="text-smallcaps">D</span>-α-Methyl-3-(3,4-dihydroxyphenyl)alanine
  • <span class="text-smallcaps">D</span>-α-Methyldopa
  • Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, <span class="text-smallcaps">D</span>-
  • Alanine,3-(3,4-dihydroxyphenyl)-2-methyl-, D- (8CI)
  • See more synonyms
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