CAS 2799-15-7

D-α-Methyldopa

Description:

D-α-Methyldopa, with the CAS number 2799-15-7, is an antihypertensive medication primarily used to treat high blood pressure. It is a centrally acting alpha-2 adrenergic agonist, which means it works by stimulating alpha-2 receptors in the brain, leading to a decrease in sympathetic outflow and a subsequent reduction in blood pressure. The chemical structure of D-α-Methyldopa includes a phenylalanine derivative, characterized by a carboxylic acid group and an amino group, making it a zwitterionic compound at physiological pH. It is typically administered in its salt form, often as methyldopa hydrochloride. D-α-Methyldopa is known for its relatively favorable side effect profile, particularly in pregnant women, where it is considered safe for managing hypertension. Common side effects may include sedation, dry mouth, and potential liver function alterations. Its pharmacokinetics involve conversion to alpha-methyl norepinephrine, which contributes to its antihypertensive effects. Overall, D-α-Methyldopa remains an important therapeutic option in the management of hypertension, especially in specific patient populations.

Formula: C₁₀H₁₃NO₄

InChI: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m1/s1

InChI key: InChIKey=CJCSPKMFHVPWAR-SNVBAGLBSA-N

SMILES: C([C@@](C(O)=O)(C)N)C1=CC(O)=C(O)C=C1

Synonyms:

• (+)-a-Methyldopa
• (2R)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
• 3-Hydroxy-α-methyl-<span class="text-smallcaps">D</span>-tyrosine
• <span class="text-smallcaps">D</span>-(3,4-Dihydroxyphenyl)-2-methylalanine
• <span class="text-smallcaps">D</span>-Methyldopa
• <span class="text-smallcaps">D</span>-Tyrosine, 3-hydroxy-α-methyl-
• <span class="text-smallcaps">D</span>-α-Methyl-3-(3,4-dihydroxyphenyl)alanine
• <span class="text-smallcaps">D</span>-α-Methyldopa
• Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, <span class="text-smallcaps">D</span>-
• Alanine,3-(3,4-dihydroxyphenyl)-2-methyl-, D- (8CI)
• D-(3,4-Dihydroxyphenyl)-2-methylalanine
• D-Methyldopa
• D-a-Methyl-3-(3,4-dihydroxyphenyl)alanine
• D-a-Methyldopa
• Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, D-
• D-Tyrosine, 3-hydroxy-α-methyl-
• 3-Hydroxy-α-methyl-D-tyrosine
• (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propionic acid
• D-α-Methyl DOPA
• D-3-(3,4-Dihydroxyphenyl)-2-methyl-alanine
• (2S)-2-azanyl-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid
• D-a-Methyl DOPA
• Carbidopa Impurity 3
• D-Tyrosine, 3-hydroxy-a-methyl- (9CI)

D-α-Methyl DOPA

CAS: 2799-15-7

Molecular weight: 211.21

Ref: 7W-GM7780

D-α-Methyl DOPA

CAS: 2799-15-7

Impurity Methyldopa EP Impurity D
Applications Antihypertensive agent. Methyldopa EP Impurity D.Product reacts with methanol to form methyl ester very fast.
References Beckett, et al.: J. Pharm. Pharmacol., 7, 433 (1955), Sletzinger, et al.: J. Med. Chem., 6, 101 (1963),

Formula: C₁₀H₁₃NO₄

Color and Shape: Neat

Molecular weight: 211.21

Ref: TR-M303790

(2R)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid

CAS: 2799-15-7

Please enquire for more information about (2R)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₀H₁₃NO₄

Purity: Min. 95%

Molecular weight: 211.21 g/mol

Ref: 3D-CAA79915

Methyldopa EP Impurity D

CAS: 2799-15-7

Formula: C₁₀H₁₃NO₄

Molecular weight: 211.22

Ref: ST-EA-CP-M93004

D-α-Methyl DOPA

CAS: 2799-15-7

D-α-Methyl DOPA is an inhibitor of DQ8 peptide binding to MHC class II molecules. By occupying a binding site in the DQ8 peptide groove, D-α-Methyl DOPA prevents the DQ8 peptide from associating with MHCII molecules. This action blocks presentation to CD4+ T cells, thereby slowing or hindering the onset or progression of type 1 diabetes or celiac disease.

Formula: C₁₀H₁₃NO₄

Molecular weight: 211.22

Ref: TM-T213890