CAS 2801785-12-4

Formula: C20H19BrFN5O2

InChI: InChI=1S/C20H19BrFN5O2/c1-23-19(28)15-4-2-3-5-17(15)26-18-16(21)12-24-20(27-18)25-13-6-8-14(9-7-13)29-11-10-22/h2-9,12H,10-11H2,1H3,(H,23,28)(H2,24,25,26,27)

InChI key: ZOPWHRVZHTXPOW-UHFFFAOYSA-N

SMILES: CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)OCCF

FAK-IN-26

CAS: 2801785-12-4

FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC₅₀ of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.

Formula: C₂₀H₁₉BrFN₅O₂

Color and Shape: Solid

Molecular weight: 460.30

Ref: TM-T207475