CAS 283173-50-2

Rucaparib

Description:

Rucaparib is a small molecule inhibitor primarily used in cancer therapy, particularly for treating certain types of ovarian and prostate cancers. It functions as a poly(ADP-ribose) polymerase (PARP) inhibitor, which interferes with the DNA repair mechanisms in cancer cells, leading to cell death, especially in those with BRCA mutations. The chemical formula of Rucaparib is C19H20N4O3, and it has a molecular weight of approximately 348.39 g/mol. Rucaparib is typically administered orally and is known for its ability to selectively target cancer cells while sparing normal cells, which contributes to its therapeutic efficacy. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for determining dosing regimens. Common side effects may include fatigue, nausea, and anemia, reflecting its impact on rapidly dividing cells. As a targeted therapy, Rucaparib represents a significant advancement in personalized medicine, particularly for patients with specific genetic profiles that predispose them to certain cancers.

Formula: C₁₉H₁₈FN₃O

InChI: InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)

InChI key: InChIKey=HMABYWSNWIZPAG-UHFFFAOYSA-N

SMILES: O=C1C2=C3C(=C(NC3=CC(F)=C2)C4=CC=C(CNC)C=C4)CCN1

Synonyms:

• 6H-Azepino[5,4,3-cd]indol-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-
• 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one
• 8-Fluoro-2-[4-[(methylamino)methyl]phenyl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
• Rubraca
• Rucaparib
• 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-

6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-

CAS: 283173-50-2

Formula: C₁₉H₁₈FN₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 323.3641

Ref: IN-DA0037FK

Rucaparib

CAS: 283173-50-2

Rucaparib

Purity: ≥98%

Molecular weight: 323.36g/mol

Ref: 54-BUP15376

Rucaparib

CAS: 283173-50-2

Rucaparib

Purity: 99%

Molecular weight: 323.36g/mol

Ref: 54-PC109071

Rucaparib

CAS: 283173-50-2

Formula: C₁₉H₁₈FN₃O

Molecular weight: 323.37

Ref: 4Z-R-153001

Rucaparib

CAS: 283173-50-2

Formula: C₁₉H₁₈FN₃O

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 323.37

Ref: 3B-R0284

Rucaparib

CAS: 283173-50-2

Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.

Formula: C₁₉H₁₈FN₃O

Purity: 98.24% - 99.80%

Color and Shape: Solid

Molecular weight: 323.36

Ref: TM-T4463

RUCAPARIB

CAS: 283173-50-2

Purity: 98%

Molecular weight: 323.371002197266

Ref: 10-F797273

Rucaparib

Controlled Product

CAS: 283173-50-2

Applications Rucaparib is PARP1 inhibitor. It can be used in biological study of chemical screening to identify drugs that enhance or mitigate cellular responses to antibody-toxin fusion proteins using human B cell precursor leukemia cells and cervical adenocarcinoma cells.
References Antignani, A., et al.: PLoS One, 11, e0161415/1-e0161415/17 (2016)

Formula: C₁₉H₁₈FN₃O

Color and Shape: Neat

Molecular weight: 323.36

Ref: TR-R701580

Rucaparib

CAS: 283173-50-2

Inhibitor of poly (ADP-ribose) polymerase enzyme; antineoplastic

Formula: C₁₉H₁₈FN₃O

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 323.36 g/mol

Ref: 3D-FR44224