CAS 28458-19-7

Z-Phe-His-Leu-OH

Description:

Z-Phe-His-Leu-OH, also known as Z-Phenylalanine-Histidine-Leucine carboxamide, is a synthetic peptide that consists of three amino acids: phenylalanine (Phe), histidine (His), and leucine (Leu), with a C-terminal carboxamide group. The "Z" prefix indicates that the phenylalanine residue is protected by a benzyloxycarbonyl (Z) group, which is commonly used in peptide synthesis to prevent unwanted reactions during the coupling process. This compound is typically utilized in biochemical research and pharmaceutical applications, particularly in studies related to peptide synthesis, drug design, and the investigation of peptide interactions with biological systems. Its structure allows for specific interactions with receptors or enzymes, making it a valuable tool in understanding peptide behavior in various biological contexts. The presence of the histidine residue may also impart unique properties, such as buffering capacity or metal ion coordination, which can be advantageous in certain experimental settings. Overall, Z-Phe-His-Leu-OH serves as an important model compound in peptide chemistry and biochemistry.

Formula: C₂₉H₃₅N₅O₆

InChI: InChI=1/C29H35N5O6/c1-19(2)13-25(28(37)38)33-27(36)24(15-22-16-30-18-31-22)32-26(35)23(14-20-9-5-3-6-10-20)34-29(39)40-17-21-11-7-4-8-12-21/h3-12,16,18-19,23-25H,13-15,17H2,1-2H3,(H,30,31)(H,32,35)(H,33,36)(H,34,39)(H,37,38)

SMILES: CC(C)CC(C(=O)O)N=C(C(Cc1cnc[nH]1)N=C(C(Cc1ccccc1)N=C(O)OCc1ccccc1)O)O

Synonyms:

• 2-[[2-[(2-benzyloxycarbonylamino-3-phenyl-propanoyl)amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methyl-pentanoic acid

Z-Phe-His-Leu-OH

CAS: 28458-19-7

Substrate for angiotensin I-converting enzyme. Cleavage of Z-FHL by ACE yields His-Leu (G-2310), which can be quantified by generating a fluorescent adduct with o-phthalaldehyde.

Formula: C₂₉H₃₅N₅O₆

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 549.63

Ref: 01-4000599

L-Leucine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-L-histidyl-

CAS: 28458-19-7

Formula: C₂₉H₃₅N₅O₆

Molecular weight: 549.6181

Ref: IN-DA002VCK

Z-Phe-His-Leu-OH

CAS: 28458-19-7

Z-Phe-His-Leu-OH is a monoclonal antibody that is used in the diagnosis and treatment of prostate cancer. This drug binds to the extracellular domain of the human prostate epithelial cell antigen (PSA), which is overexpressed in prostate cancers. Z-Phe-His-Leu-OH can be used in combination with other drugs for the treatment of prostate hyperplasia, such as angiotensin II receptor antagonists or 5α reductase inhibitors. The conformational epitope of this antibody has been demonstrated by immunohistochemical analysis on human tissues.

Formula: C₂₉H₃₅N₅O₆

Purity: Min. 95%

Molecular weight: 549.62 g/mol

Ref: 3D-FP110845