CAS 28575-34-0

acetyl pepstatin

Description:

Acetyl pepstatin is a synthetic peptide derivative known for its role as a potent inhibitor of aspartic proteases, particularly renin and pepsin. It is characterized by its structure, which includes an acetyl group and a sequence of amino acids that contribute to its biological activity. The compound is typically used in biochemical research to study protease functions and their inhibition mechanisms. Acetyl pepstatin exhibits high specificity for its target enzymes, making it valuable in pharmacological studies and potential therapeutic applications. Its solubility properties are influenced by the presence of the acetyl group, which can enhance its stability and bioavailability. Additionally, the compound is often utilized in the development of drugs aimed at treating conditions related to dysregulated protease activity. Safety and handling precautions are essential when working with this substance, as with many chemical compounds, to mitigate any potential hazards associated with its use in laboratory settings.

Formula: C₃₁H₅₇N₅O₉

InChI: InChI=1/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22+,23-,24+,27-,28-/m1/s1

Synonyms:

• Ac-Val-Val-Sta-Ala-Sta-OH
• (3S,4S)-4-[[(2R)-2-[[(3R,4R)-4-[[(2R)-2-[[(2R)-2-acetamido-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-heptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-heptanoic acid
• Acetyl-Pepstatin
• Aids-080613
• ACETYL-PEPSTATIN USP/EP/BP
• Acetyl-Pepstatin - CAS 28575-34-0 - Calbiochem
• N-Acetyl-Pepstatin
• PEPSTATIN, ACETYL-
• (3S,7S,11S,12S,14S,18S)-11-Acetoxy-14-carbamoyl-3-hydroxy-4,12-diisobutyl-18-isopropyl-7,15,22-trimethyl-6,9,17,20-tetraoxo-5,8,13,19-tetraazatricosan-1-oic acid
• N-ACETYL-VAL-VAL(3S,4S)-STA-ALA-(3S,4S)-STA
• AC-VAL-VAL-STA-ALA-STA
• Acetyl-Pepstatin Ac-Val-Val-Sta-Ala-Sta-OH
• Pepstatin A monoacetate (ester)
• AC-PEPSTATIN
• Aids080613
• Ac-Pepstain/AC-VAL-VAL-STA-ALA-STA
• AC-VAL-VAL-(3S,4S)-STA-ALA-(3S,4S)-STA-OH
• (3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid

L-Valinamide, N-(3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-, monoacetate (ester), [1S-[1R*,2R*,4[R*[R*(R*)]]]]- (9CI)

CAS: 28575-34-0

Formula: C₃₁H₅₇N₅O₉

Purity: 95%

Molecular weight: 643.8124

Ref: IN-DA002VQ4

Acetyl pepstatin

CAS: 28575-34-0

Acetyl pepstatin

Formula: C₃₁H₅₇N₅O₉

Purity: By hplc: >98% by area (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 643.81g/mol

Ref: 54-BIMI7332

Acetylpepstatin

CAS: 28575-34-0

Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.

Formula: C₃₃H₆₁N₅O₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 703.875

Ref: TM-T26552

Acetyl-Pepstatin

CAS: 28575-34-0

Acetyl-pepstatin is reported to be an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and of HIV-2 proteinase (Ki = 5 nM at pH 4.7). Ac-Val-Val-Sta-Ala-Sta also inhibits the P. falciparum aspartyl protease plasmepsin II, IC₅₀ 0.6 nM.

Formula: C₃₁H₅₇N₅O₉

Purity: 97.8%

Color and Shape: White Powder

Molecular weight: 643.82

Ref: 01-4015928

Acetyl-Pepstatin Ac-Val-Val-Sta-Ala-Sta-OH

CAS: 28575-34-0

Acetyl-Pepstatin is a protein data inhibitor that binds to the active site of enzymes, inhibiting their function. Acetyl-pepstatin has been shown to inhibit cathepsin D, chymotrypsin, and trypsin. It also inhibits the activity of proteases in the stomach and intestinal tract. Acetyl-Pepstatin is used as an anti-inflammatory drug for the treatment of chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF). The inhibition of these enzymes reduces inflammation by preventing the activation of inflammatory cytokines. It also prevents collagen from being degraded by proteases, which leads to decreased degradation of cartilage by chondrocytes. This drug's mechanism is similar to that of acetylsalicylic acid (aspirin), in that it inhibits prostaglandin synthesis.br>

Formula: C₃₁H₅₇N₅O₉

Purity: Min. 95%

Molecular weight: 643.81 g/mol

Ref: 3D-FA111026