CAS 285983-48-4: Doramapimod

Description: Doramapimod, with the CAS number 285983-48-4, is a small molecule inhibitor primarily targeting the p38 mitogen-activated protein kinase (MAPK) pathway. This compound is notable for its potential therapeutic applications, particularly in inflammatory diseases and certain cancers. Doramapimod exhibits anti-inflammatory properties by inhibiting the phosphorylation of downstream targets involved in the inflammatory response. Its chemical structure includes a specific arrangement of functional groups that contribute to its biological activity and selectivity for the p38 MAPK isoforms. The substance has undergone various preclinical and clinical studies to evaluate its efficacy and safety profile. As a research chemical, Doramapimod serves as a valuable tool for understanding the role of p38 MAPK in cellular processes and disease mechanisms. However, like many investigational drugs, its clinical use is subject to ongoing research and regulatory approval.

Formula: C₃₁H₃₇N₅O₃

InChI: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)

InChI key: InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(OCCN2CCOCC2)C=3C=CC=CC13)NC4=CC(=NN4C5=CC=C(C=C5)C)C(C)(C)C

Synonyms:

• 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
• 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
• 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
• 1-[5-Tert-Butyl-2-(4-Methylphenyl)Pyrazol-3-Yl]-3-[4-(2-Morpholin-4-Ylethoxy)Naphthalen-1-Yl]Urea
• Birb 796
• Birb 796Bs
• Brb 796
• N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
• Unc 10225354
• Unc10225354
• Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
• Doramapimod

Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-

CAS: 285983-48-4

• Formula: C₃₁H₃₇N₅O₃
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 527.6572

Doramapimod

CAS: 285983-48-4

• Purity: 99.65%
• Molecular weight: 527.66g/mol

Doramapimod

CAS: 285983-48-4

• Formula: C₃₁H₃₇N₅O₃
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 527.67

Doramapimod

CAS: 285983-48-4

• Formula: C₃₁H₃₇N₅O₃
• Purity: 99.9% (Typical Value in Batch COA)
• Color and Shape: off-white solid
• Molecular weight: 527.66g/mol

Doramapimod

CAS: 285983-48-4

Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but …

• Formula: C₃₁H₃₇N₅O₃
• Purity: 97.73% - 98.80%
• Color and Shape: Solid
• Molecular weight: 527.66

Doramapimod

CAS: 285983-48-4

Applications Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is …

• Formula: C₃₁H₃₇N₅O₃
• Color and Shape: Neat
• Molecular weight: 527.66

Doramapimod

CAS: 285983-48-4

p38α MAP kinase inhibitor; JNK2α2 protein kinase inhibitor

• Formula: C₃₁H₃₇N₅O₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 527.66 g/mol