CAS 285983-48-4

Doramapimod

Description:

Doramapimod, with the CAS number 285983-48-4, is a small molecule inhibitor primarily targeting the p38 mitogen-activated protein kinase (MAPK) pathway. This compound is notable for its potential therapeutic applications, particularly in inflammatory diseases and certain cancers. Doramapimod exhibits anti-inflammatory properties by inhibiting the phosphorylation of downstream targets involved in the inflammatory response. Its chemical structure includes a specific arrangement of functional groups that contribute to its biological activity and selectivity for the p38 MAPK isoforms. The substance has undergone various preclinical and clinical studies to evaluate its efficacy and safety profile. As a research chemical, Doramapimod serves as a valuable tool for understanding the role of p38 MAPK in cellular processes and disease mechanisms. However, like many investigational drugs, its clinical use is subject to ongoing research and regulatory approval.

Formula: C₃₁H₃₇N₅O₃

InChI: InChI=1/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)

InChI key: InChIKey=MVCOAUNKQVWQHZ-UHFFFAOYSA-N

SMILES: N(C(NC=1C2=C(C(OCCN3CCOCC3)=CC1)C=CC=C2)=O)C=4N(N=C(C(C)(C)C)C4)C5=CC=C(C)C=C5

Synonyms:

• 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
• 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
• 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
• 1-[5-Tert-Butyl-2-(4-Methylphenyl)Pyrazol-3-Yl]-3-[4-(2-Morpholin-4-Ylethoxy)Naphthalen-1-Yl]Urea
• Birb 796
• Birb 796Bs
• Brb 796
• N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
• Unc 10225354
• Unc10225354
• Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
• Doramapimod
• BIRB 796 (DoraMapiMod)
• 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea
• BIBR-796(DoraMapiMod)
• DoraMapiMod, BIBR-796
• DoraMapin BIBR796
• 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796 (Doramapimod)
• DoraMapiMod (BIRB-796)

Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-

CAS: 285983-48-4

Formula: C₃₁H₃₇N₅O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 527.6572

Ref: IN-DA002VTB

Doramapimod

CAS: 285983-48-4

Doramapimod

Purity: ≥95%

Molecular weight: 527.66g/mol

Ref: 54-BUP15009

Doramapimod

CAS: 285983-48-4

Formula: C₃₁H₃₇N₅O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 527.67

Ref: 3B-D6115

Doramapimod

CAS: 285983-48-4

Doramapimod

Formula: C₃₁H₃₇N₅O₃

Purity: 99.9% (Typical Value in Batch COA)

Color and Shape: off-white solid

Molecular weight: 527.65718g/mol

Ref: 54-BISN0161

Doramapimod

CAS: 285983-48-4

Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.

Formula: C₃₁H₃₇N₅O₃

Purity: 97.14% - 98.80%

Color and Shape: Solid

Molecular weight: 527.66

Ref: TM-T6277

Doramapimod

Controlled Product

CAS: 285983-48-4

Applications Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.
References Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);

Formula: C₃₁H₃₇N₅O₃

Color and Shape: Neat

Molecular weight: 527.66

Ref: TR-D534250

Doramapimod

CAS: 285983-48-4

p38α MAP kinase inhibitor; JNK2α2 protein kinase inhibitor

Formula: C₃₁H₃₇N₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 527.66 g/mol

Ref: 3D-FD32902