CAS 287714-41-4
:Rosuvastatin
Description:
Rosuvastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its chemical formula is C22H28FN3O6S, and it features a distinctive structure that includes a fluorophenyl group and a sulfonamide moiety, contributing to its potency. Rosuvastatin functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby lowering levels of low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. The drug is characterized by its high bioavailability and long half-life, allowing for once-daily dosing. It is generally well-tolerated, though potential side effects may include muscle pain, liver enzyme elevations, and gastrointestinal disturbances. Rosuvastatin is often prescribed in conjunction with lifestyle modifications, such as diet and exercise, to enhance its cholesterol-lowering effects. Its efficacy and safety profile make it a widely used medication in the management of dyslipidemia.
Formula:C22H24D3FN3NaO6S
InChI:InChI=1/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17+/m0/s1
InChI key:InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-N
SMILES:C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2
Synonyms:- (3R,5R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
- (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid
- (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic acid
- (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
- 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
- 7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methyl-Methylsulfonyl-Amino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-Hept-6-Enoic Acid
- Azd 4522
- Azd4522
- Rosuvastatin Acid
- Rosuvastatin intermediates
- X-Plended
- Zd 4522
- Rosuvastatin
- See more synonyms
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Found 15 products.
Rosuvastatin Calcium
CAS:Formula:C44H54CaF2N6O12S2Purity:>95.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:1,001.146-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
CAS:Formula:C22H28FN3O6SPurity:99%Color and Shape:SolidMolecular weight:481.5376Rosuvastatin-d3 sodium salt
CAS:Formula:C22H24D3FN3O6S·NaColor and Shape:Yellow SolidMolecular weight:483.56 22.99Rosuvastatin
CAS:<p>Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.</p>Formula:C22H28FN3O6SPurity:95.24% - 99.8%Color and Shape:SolidMolecular weight:481.54rac-Rosuvastatin Sodium Salt (Mixture: R700515 and Sodium Salt of R700500)
CAS:Controlled ProductFormula:C22H27FN3NaO6SColor and Shape:NeatMolecular weight:503.519rac-Rosuvastatin Sodium Salt (E/Z Mixture)
CAS:Controlled ProductFormula:C22H27FN3NaO6SColor and Shape:NeatMolecular weight:503.527,8-Dihydro-rosuvastatin Diisopropylammonium Salt
CAS:Controlled ProductFormula:C28H45FN4O6SColor and Shape:NeatMolecular weight:584.74N-Desmethyl N-ethyl Rosuvastatin Sodium Salt
CAS:Controlled ProductFormula:C23H29FN3NaO6SColor and Shape:NeatMolecular weight:517.546(3S,5R)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt
CAS:Controlled ProductFormula:C22H27FN3NaO6SColor and Shape:NeatMolecular weight:503.519(3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt
CAS:Controlled Product<p>Applications (3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.<br>References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)<br></p>Formula:C22H27FN3NaO6SColor and Shape:NeatMolecular weight:503.519(3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt
CAS:Controlled Product<p>Applications (3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.<br>References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)<br></p>Formula:C22H27FN3NaO6SColor and Shape:NeatMolecular weight:503.519Rosuvastatin
CAS:<p>Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis.</p>Formula:C22H28FN3O6SPurity:Min. 95%Molecular weight:481.54 g/mol
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