CAS 287714-41-4: Rosuvastatin

Description: Rosuvastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its chemical formula is C22H28FN3O6S, and it features a distinctive structure that includes a fluorophenyl group and a sulfonamide moiety, contributing to its potency. Rosuvastatin functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby lowering levels of low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. The drug is characterized by its high bioavailability and long half-life, allowing for once-daily dosing. It is generally well-tolerated, though potential side effects may include muscle pain, liver enzyme elevations, and gastrointestinal disturbances. Rosuvastatin is often prescribed in conjunction with lifestyle modifications, such as diet and exercise, to enhance its cholesterol-lowering effects. Its efficacy and safety profile make it a widely used medication in the management of dyslipidemia.

Formula: C₂₂H₂₈FN₃O₆S

InChI: InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1

InChI key: InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-N

SMILES: O=C(O)CC(O)CC(O)C=CC=1C(=NC(=NC1C(C)C)N(C)S(=O)(=O)C)C=2C=CC(F)=CC2

Synonyms:

• (3R,5R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid
• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic acid
• (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
• 7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methyl-Methylsulfonyl-Amino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-Hept-6-Enoic Acid
• Azd 4522
• Azd4522
• Rosuvastatin Acid
• Rosuvastatin intermediates
• X-Plended
• Zd 4522
• Rosuvastatin

Rosuvastatin Calcium

CAS: 147098-20-2 287714-41-4

• Formula: C₄₄H₅₄CaF₂N₆O₁₂S₂
• Purity: >95.0%(HPLC)(N)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 1,001.14

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-

CAS: 287714-41-4

• Formula: C₂₂H₂₈FN₃O₆S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 481.5376

Rosuvastatin-d3 sodium salt

CAS: 287714-41-4

• Formula: C₂₂H₂₄D₃FN₃O₆S·Na
• Color and Shape: Yellow Solid
• Molecular weight: 483.56 22.99

Rosuvastatin-d4 sodium salt

CAS: 287714-41-4

• Formula: C₂₂H₂₃D₄FN₃O₆S·Na
• Molecular weight: 484.56 22.99

Rosuvastatin EP Impurity I Calcium Salt

CAS: 287714-41-4

• Formula: C₂₂H₂₇FN₃O₆SCa
• Molecular weight: 480.54 1/2 40.08

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. …

• Formula: C₂₂H₂₈FN₃O₆S
• Purity: 95.24% - 99.8%
• Color and Shape: Solid
• Molecular weight: 481.54

(3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

CAS: 287714-41-4

Applications (3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase …

• Formula: C₂₂H₂₇FN₃NaO₆S
• Color and Shape: Neat
• Molecular weight: 503.519

rac-Rosuvastatin Sodium Salt (Mixture: R700515 and Sodium Salt of R700500)

CAS: 287714-41-4

• Formula: C₂₂H₂₇FN₃NaO₆S
• Color and Shape: Neat
• Molecular weight: 503.519

rac-Rosuvastatin Sodium Salt (E/Z Mixture)

CAS: 1007871-86-4 287714-41-4

• Formula: C₂₂H₂₇FN₃NaO₆S
• Color and Shape: Neat
• Molecular weight: 503.52

7,8-Dihydro-rosuvastatin Diisopropylammonium Salt

CAS: 287714-41-4

• Formula: C₂₈H₄₅FN₄O₆S
• Color and Shape: Neat
• Molecular weight: 584.74

N-Desmethyl N-ethyl Rosuvastatin Sodium Salt

CAS: 287714-41-4

• Formula: C₂₃H₂₉FN₃NaO₆S
• Color and Shape: Neat
• Molecular weight: 517.546

(3S,5R)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

CAS: 287714-41-4

• Formula: C₂₂H₂₇FN₃NaO₆S
• Color and Shape: Neat
• Molecular weight: 503.519

(3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

CAS: 287714-41-4

Applications (3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase …

• Formula: C₂₂H₂₇FN₃NaO₆S
• Color and Shape: Neat
• Molecular weight: 503.519

Rosuvastatin

CAS: 287714-41-4

Please enquire for more information about Rosuvastatin including the price, delivery time and more detailed …

• Formula: C₂₂H₂₈FN₃O₆S
• Purity: Min. 95%
• Molecular weight: 481.54 g/mol