CAS 287714-41-4

Rosuvastatin

Description:

Rosuvastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its chemical formula is C22H28FN3O6S, and it features a distinctive structure that includes a fluorophenyl group and a sulfonamide moiety, contributing to its potency. Rosuvastatin functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby lowering levels of low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. The drug is characterized by its high bioavailability and long half-life, allowing for once-daily dosing. It is generally well-tolerated, though potential side effects may include muscle pain, liver enzyme elevations, and gastrointestinal disturbances. Rosuvastatin is often prescribed in conjunction with lifestyle modifications, such as diet and exercise, to enhance its cholesterol-lowering effects. Its efficacy and safety profile make it a widely used medication in the management of dyslipidemia.

Formula: C₂₂H₂₄D₃FN₃NaO₆S

InChI: InChI=1/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17+/m0/s1

InChI key: InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2

Synonyms:

• (3R,5R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid
• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic acid
• (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
• 7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methyl-Methylsulfonyl-Amino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-Hept-6-Enoic Acid
• Azd 4522
• Azd4522
• Rosuvastatin Acid
• Rosuvastatin intermediates
• X-Plended
• Zd 4522
• Rosuvastatin

Rosuvastatin Calcium

CAS: 147098-20-2, 287714-41-4

Formula: C₄₄H₅₄CaF₂N₆O₁₂S₂

Purity: >95.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 1,001.14

Ref: 3B-R0180

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-

CAS: 287714-41-4

Formula: C₂₂H₂₈FN₃O₆S

Purity: 99%

Color and Shape: Solid

Molecular weight: 481.5376

Ref: IN-DA002WF6

Rosuvastatin-d3 sodium salt

CAS: 287714-41-4

Formula: C₂₂H₂₄D₃FN₃O₆S·Na

Color and Shape: Yellow Solid

Molecular weight: 483.56 22.99

Ref: 4Z-R-092

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin

Purity: ≥95%

Molecular weight: 481.54g/mol

Ref: 54-BUP06104

Rosuvastatin-d4 sodium salt

CAS: 287714-41-4

Formula: C₂₂H₂₃D₄FN₃O₆S·Na

Molecular weight: 484.56 22.99

Ref: 4Z-R-093

Rosuvastatin EP Impurity I Calcium Salt

CAS: 287714-41-4

Formula: C₂₂H₂₇FN₃O₆SCa

Molecular weight: 480.54 1/2 40.08

Ref: 4Z-R-0934

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.

Formula: C₂₂H₂₈FN₃O₆S

Purity: 95.24% - 99.8%

Color and Shape: Solid

Molecular weight: 481.54

Ref: TM-T1676

rac-Rosuvastatin Sodium Salt (Mixture: R700515 and Sodium Salt of R700500)

Controlled Product

CAS: 287714-41-4

Formula: C₂₂H₂₇FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 503.519

Ref: TR-R700720

rac-Rosuvastatin Sodium Salt (E/Z Mixture)

Controlled Product

CAS: 1007871-86-4, 287714-41-4

Formula: C₂₂H₂₇FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 503.52

Ref: TR-R700725

7,8-Dihydro-rosuvastatin Diisopropylammonium Salt

Controlled Product

CAS: 287714-41-4

Formula: C₂₈H₄₅FN₄O₆S

Color and Shape: Neat

Molecular weight: 584.74

Ref: TR-D450540

N-Desmethyl N-ethyl Rosuvastatin Sodium Salt

Controlled Product

CAS: 287714-41-4

Formula: C₂₃H₂₉FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 517.546

Ref: TR-D292395

(3S,5R)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

Controlled Product

CAS: 287714-41-4

Formula: C₂₂H₂₇FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 503.519

Ref: TR-F592045

(3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

Controlled Product

CAS: 287714-41-4

Applications (3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)

Formula: C₂₂H₂₇FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 503.519

Ref: TR-F592055

(3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

Controlled Product

CAS: 287714-41-4

Applications (3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)

Formula: C₂₂H₂₇FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 503.519

Ref: TR-F592040

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis.

Formula: C₂₂H₂₈FN₃O₆S

Purity: Min. 95%

Molecular weight: 481.54 g/mol

Ref: 3D-FF139301