CAS 28782-42-5

Difenoxin

Description:

Difenoxin is a synthetic opioid analgesic primarily used as an antidiarrheal agent. It is chemically classified as a diphenylpropylamine derivative and is often combined with atropine to discourage misuse. Difenoxin acts on the mu-opioid receptors in the gastrointestinal tract, leading to decreased motility and increased transit time, which helps alleviate diarrhea. The substance is typically administered in oral form and is known for its effectiveness in treating non-specific diarrhea. Its pharmacological effects include analgesia, sedation, and potential for dependence, similar to other opioids, although it is less potent than morphine. Difenoxin is subject to regulatory controls due to its potential for abuse and is classified as a Schedule IV controlled substance in some jurisdictions. Safety considerations include the risk of side effects such as constipation, dizziness, and drowsiness. As with any medication, it is essential to use difenoxin under medical supervision to mitigate risks and ensure appropriate therapeutic use.

Formula: C₂₈H₂₈N₂O₂

InChI: InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32)

InChI key: InChIKey=UFIVBRCCIRTJTN-UHFFFAOYSA-N

SMILES: C(CCN1CCC(C(O)=O)(CC1)C2=CC=CC=C2)(C#N)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• 1-(3-Cyan-3,3-diphenylpropyl)-4-phenyl-4-piperidincarbonsaeure
• 1-(3-Cyano-3,3-Diphenylpropyl)-4-Phenylpiperidine-4-Carboxylic Acid
• 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid
• 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid
• 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-
• DEA No. 9168
• Difenossina
• Difenossina [DCIT]
• Difenoxilic acid
• Difenoxin [USAN:INN:BAN]
• Difenoxina
• Difenoxina [INN-Spanish]
• Difenoxine
• Difenoxinum
• Difenoxinum [INN-Latin]
• Difenoxylic acid
• Diphenoxin
• Diphenoxylic acid
• Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-
• Lyspafen
• McN-JR 15,403-11
• Unii-3Zz5Bj9F2Q

Difenoxin

Controlled Product

CAS: 28782-42-5

Applications Difenoxin is the active metabolite of Diphenoxylate. Antiperistaltic; antidiarrheal. This is a controlled substance (opiate).
References Soudijin, W., et al.: Arzneim.-Forsch., 22, 513 (1972; Megens, A.A., et al.: Eur. J. Pharma.,178, 357 (1990)

Formula: C₂₈H₂₈N₂O₂

Color and Shape: Neat

Molecular weight: 424.534

Ref: TR-D445413

Difenoxin-d5

Controlled Product

CAS: 28782-42-5

Formula: C₂₈H₂₃D₅N₂O₂

Color and Shape: Neat

Molecular weight: 429.57

Ref: TR-D445404

Diphenoxylate Related Compound A

Controlled Product

CAS: 28782-42-5

Alfentanil (inn), anileridine (inn), bezitramide (inn), bromazepam (inn), difenoxin (inn), diphenoxylate (inn), dipipanone (inn), fentanyl (inn), etc.

Formula: C₂₈H₂₈N₂O₂

Color and Shape: Powder

Molecular weight: 424.21508

Ref: 45-1219019