CAS 288383-20-0

Cediranib

Description:

Cediranib, with the CAS number 288383-20-0, is a small molecule inhibitor primarily known for its role as a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. It is classified as an anti-cancer agent, particularly in the treatment of various solid tumors, including non-small cell lung cancer and ovarian cancer. Cediranib exhibits characteristics such as a relatively low molecular weight and a specific chemical structure that allows it to effectively block angiogenesis, the process through which new blood vessels form from pre-existing ones, which is crucial for tumor growth and metastasis. The compound is typically administered orally and has been studied in clinical trials for its efficacy and safety profile. Its mechanism of action involves the inhibition of VEGF signaling pathways, leading to reduced tumor vascularization and growth. As with many targeted therapies, potential side effects may include hypertension, fatigue, and gastrointestinal disturbances, necessitating careful monitoring during treatment.

Formula: C₂₅H₂₇FN₄O₃

InChI: InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3

InChI key: InChIKey=XXJWYDDUDKYVKI-UHFFFAOYSA-N

SMILES: O(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=CN1)C=4C(F)=C5C(=CC4)NC(C)=C5

Synonyms:

• 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
• 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline
• 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline
• 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline
• Azd 2171
• Azd2171
• Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-
• Zd 2171
• Cediranib

Cediranib

CAS: 288383-20-0

Formula: C₂₅H₂₇FN₄O₃

Purity: >95.0%(HPLC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 450.51

Ref: 3B-C3918

Cediranib

CAS: 288383-20-0

Cediranib

Formula: C₂₅H₂₇FN₄O₃

Purity: 99.82% (Typical Value in Batch COA)

Color and Shape: Solid-Powder

Molecular weight: 450.50528

Ref: 54-BIFK0013

Cediranib

CAS: 288383-20-0

Formula: C₂₅H₂₇FN₄O₃

Molecular weight: 450.51

Ref: 7W-GP6207

Cediranib

CAS: 288383-20-0

Cediranib

Formula: C₂₅H₂₇FN₄O₃

Purity: ≥95%

Molecular weight: 450.51

Ref: 54-BUP15324

4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline

CAS: 288383-20-0

Formula: C₂₅H₂₇FN₄O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 450.5053

Ref: IN-DA00I5DR

Cediranib

CAS: 288383-20-0

Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.

Formula: C₂₅H₂₇FN₄O₃

Purity: 97.21% - 99.94%

Color and Shape: Solid

Molecular weight: 450.51

Ref: TM-T2500

Cediranib

CAS: 288383-20-0

Inhibitor of VEGF receptor tyrosine kinases and non-receptor tyrosine kinases

Formula: C₂₅H₂₇FN₄O₃

Purity: Min. 98 Area-%

Color and Shape: White To Off-White Solid

Molecular weight: 450.20672

Ref: 3D-FC32854

Cediranib

CAS: 288383-20-0

4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline

Formula: C₂₅H₂₇FN₄O₃

Purity: 95%

Molecular weight: 450.51

Ref: IN-DG448234

Cediranib

CAS: 288383-20-0

Formula: C₂₅H₂₇FN₄O₃

Purity: 95%

Molecular weight: 450.514

Ref: 10-F050681

Cediranib

Controlled Product

CAS: 288383-20-0

Applications Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.
References Shao, J., et al.: Shiyong Yixue Zazhi, 31, 4143 (2015); Gerstner, E. R., et al.: Transl. Cancer Res., 5, 211 (2016)

Formula: C₂₅H₂₇FN₄O₃

Color and Shape: Neat

Molecular weight: 450.51

Ref: TR-C231355