CAS 289656-45-7

Senicapoc

Description:

Senicapoc, with the CAS number 289656-45-7, is a chemical compound that functions primarily as a selective inhibitor of the KCa3.1 potassium channel. This compound has garnered attention in pharmacological research due to its potential therapeutic applications, particularly in the treatment of various diseases, including asthma and other inflammatory conditions. Senicapoc is characterized by its ability to modulate ion flow across cell membranes, which can influence cellular processes such as muscle contraction and immune response. The compound is typically studied in the context of its effects on smooth muscle cells and immune cells, where it may help to reduce hyperreactivity and inflammation. Its chemical structure includes specific functional groups that contribute to its biological activity and selectivity for the KCa3.1 channel. As with many pharmacological agents, the safety profile, pharmacokinetics, and potential side effects are critical areas of ongoing research to fully understand its therapeutic potential and limitations.

Formula: C₂₀H₁₅F₂NO

InChI: InChI=1/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)

InChI key: InChIKey=SCTZUZTYRMOMKT-UHFFFAOYSA-N

SMILES: C(C(N)=O)(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3

Synonyms:

• 4-Fluoro-α-(4-fluorophenyl)-α-phenylbenzeneacetamide
• Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
• Ica-17043
• Senicapoc
• 2,2-Bis(4-fluorophenyl)-2-phenylacetamide
• 4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide
• ICA-17043;ICA 17043;ICA17043
• 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
• 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-

CAS: 289656-45-7

Formula: C₂₀H₁₅F₂NO

Purity: 99%

Color and Shape: Solid

Molecular weight: 323.3360

Ref: IN-DA002V0O

Senicapoc

CAS: 289656-45-7

Senicapoc

Purity: ≥95%

Molecular weight: 323.34g/mol

Ref: 54-BUP10806

2,2-Bis(4-Fluorophenyl)-2-Phenylacetamide

CAS: 289656-45-7

2,2-Bis(4-Fluorophenyl)-2-Phenylacetamide

Purity: 98%

Molecular weight: 323.34g/mol

Ref: 54-PC108974

Senicapoc

CAS: 289656-45-7

Senicapoc (ICA-17043) blocks Gardos channel, reduces RBC dehydration, IC50: 11 nM for rubidium flux, 30 nM for dehydration. Used in Sickle Cell therapy.

Formula: C₂₀H₁₅F₂NO

Purity: 95.7% - 99.47%

Color and Shape: Solid

Molecular weight: 323.34

Ref: TM-T3528

Senicapoc

CAS: 289656-45-7

Gardos channel inhibitor

Formula: C₂₀H₁₅F₂NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 323.34 g/mol

Ref: 3D-FS100781

Senicapoc - Bio-X ™

CAS: 289656-45-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₀H₁₅F₂NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 323.34 g/mol

Ref: 3D-BS300121

2,2-Bis(4-fluorophenyl)-2-phenylacetamide

CAS: 289656-45-7

Formula: C₂₀H₁₅F₂NO

Purity: 99%

Molecular weight: 323.343

Ref: 10-F224276