CAS 289893-25-0

Arimoclomol

Description:

Arimoclomol is a chemical compound classified as a small molecule and is primarily known for its role as a pharmacological agent. It functions as a co-inducer of heat shock proteins, which are crucial for cellular protection and stress response. Arimoclomol has been investigated for its potential therapeutic applications in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington's disease, due to its ability to enhance cellular resilience against stressors. The compound exhibits a favorable safety profile in clinical studies, and its mechanism of action involves the modulation of protein folding and degradation pathways, thereby promoting cell survival under adverse conditions. Additionally, arimoclomol is characterized by its solubility in organic solvents and moderate stability under physiological conditions. Its development highlights the importance of heat shock protein modulation in treating diseases characterized by protein misfolding and aggregation. Overall, arimoclomol represents a promising avenue in the field of neuroprotection and therapeutic strategies for neurodegenerative disorders.

Formula: C₁₄H₂₀ClN₃O₃

InChI: InChI=1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/t13-/m1/s1

InChI key: InChIKey=SGEIEGAXKLMUIZ-CYBMUJFWSA-N

SMILES: C(=NOC[C@@H](CN1CCCCC1)O)(Cl)C2=CN(=O)=CC=C2

Synonyms:

• Arimoclomol [INN]
• Arimoclomol
• Arimoclomolum
• Arimoclomolum [INN-Latin]
• Brx 345
• N-((2R)-2-Hydroxy-3-(1-piperidyl)propoxy)pyridine-3-carboximidoyl chloride, 1-oxide
• Unii-Eut3557Rt5
• 3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide
• N-{[(2R)-2-hydroxy-3-(piperidin-1-yl)propyl]oxy}pyridine-3-carboximidoyl chloride 1-oxide
• BRX 345 free base

N-[(2R)-2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidoylchloride 1-oxide

CAS: 289893-25-0

Formula: C₁₄H₂₀ClN₃O₃

Purity: 95%

Color and Shape: Liquid

Molecular weight: 313.7799

Ref: IN-DA002V3O

Arimoclomol

CAS: 289893-25-0

Arimoclomol

Purity: ≥98%

Molecular weight: 313.78g/mol

Ref: 54-BUP08807

Arimoclomol

CAS: 289893-25-0

Formula: C₁₄H₂₀ClN₃O₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 313.78

Ref: 7W-GP7277

(2R-)Arimoclomol

CAS: 289893-25-0

A co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.

Formula: C₁₄H₂₀ClN₃O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 313.78 g/mol

Ref: 3D-FA30834

Arimoclomol

CAS: 289893-25-0

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (

Formula: C₁₄H₂₀ClN₃O₃

Purity: 99.15%

Color and Shape: Solid

Molecular weight: 313.78

Ref: TM-T13553