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CAS 2914873-59-7

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  • JAK3-IN-18
    Targetmol
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    JAK3-IN-18

    CAS:
    JAK3-IN-18 is a selective and orally active dual inhibitor targeting JAK3 and TEC, with IC50 values of 0.5391 nM and 12.40 nM, respectively. It demonstrates remarkable selectivity for AK1, AK2, and TYK2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 exhibits exceptional therapeutic efficacy in a mouse model of experimental autoimmune encephalomyelitis and is applicable for multiple sclerosis research.
    Formula:C18H16FN5O
    Molecular weight:337.35

    Ref: TM-T211808

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