CAS 2914879-10-8
:KIF18A-IN-6
Description:
KIF18A-IN-6, with the CAS number 2914879-10-8, is a small molecule inhibitor specifically targeting the kinesin motor protein KIF18A, which plays a crucial role in mitotic spindle dynamics during cell division. This compound is characterized by its ability to disrupt the function of KIF18A, thereby influencing cellular processes such as mitosis and potentially offering therapeutic avenues in cancer treatment, where abnormal cell division is prevalent. The molecular structure of KIF18A-IN-6 typically includes functional groups that enhance its binding affinity to the target protein, contributing to its inhibitory effects. Additionally, its pharmacokinetic properties, such as solubility, stability, and bioavailability, are essential for its efficacy as a drug candidate. Research into KIF18A-IN-6 may also explore its selectivity, potential off-target effects, and overall safety profile in biological systems. As with many small molecule inhibitors, ongoing studies are likely focused on optimizing its chemical properties to improve therapeutic outcomes.
Formula:C28H37N3O5S2
InChI:InChI=1S/C28H37N3O5S2/c1-5-37(33,34)29-21-9-10-24-23(18-21)28(15-13-27(11-12-27)14-16-28)19-31(24)25(32)20-7-6-8-22(17-20)38(35,36)30-26(2,3)4/h6-10,17-18,29-30H,5,11-16,19H2,1-4H3
InChI key:AXRRVVWONHGXHG-UHFFFAOYSA-N
SMILES:CCS(=O)(=O)NC1=CC2=C(C=C1)N(CC23CCC4(CC4)CC3)C(=O)C5=CC(=CC=C5)S(=O)(=O)NC(C)(C)C
Synonyms:- KIF18A-IN-6
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KIF18A-IN-6
CAS:KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Formula:C28H37N3O5S2Purity:97.59%Color and Shape:Yellow SolidMolecular weight:559.74
