CAS 29205-06-9

Fluocortolone pivalate

Description:

Fluocortolone pivalate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatological and systemic treatments. It is characterized by its ability to modulate the immune response and reduce inflammation, making it effective in treating various skin conditions and autoimmune disorders. The substance is a derivative of fluocortolone, which is a potent glucocorticoid, and the pivalate ester enhances its lipophilicity, improving skin penetration and bioavailability. Fluocortolone pivalate typically exhibits a high affinity for glucocorticoid receptors, leading to a range of biological effects, including the inhibition of pro-inflammatory cytokines and the promotion of anti-inflammatory pathways. It is usually formulated in topical preparations, such as creams or ointments, and is administered to minimize systemic exposure while maximizing local therapeutic effects. As with other corticosteroids, its use may be associated with potential side effects, including skin atrophy and local irritation, particularly with prolonged use. Proper medical guidance is essential for its application to ensure efficacy and safety.

Formula: C₂₇H₃₇FO₅

InChI: InChI=1S/C27H37FO5/c1-14-9-17-16-11-19(28)18-10-15(29)7-8-26(18,5)23(16)20(30)12-27(17,6)22(14)21(31)13-33-24(32)25(2,3)4/h7-8,10,14,16-17,19-20,22-23,30H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,22-,23-,26+,27+/m1/s1

InChI key: InChIKey=XZBJVIQXJHGUBE-HZMVJJPJSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(C[C@@H](C)[C@@H]2C(COC(C(C)(C)C)=O)=O)[H]

Synonyms:

• (6Alpha,11Beta,16Alpha)-6-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 2,2-Dimethylpropanoate
• (6α,11β,16α)-21-(2,2-Dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• 20380-10-3
• 6α-Fluoro-11β-hydroxy-21-trimethylacetoxy-16α-methylpregna-1,4-diene-3,20-dione
• Flucortolone pivalate
• Fluocortolone 21-trimethylacetate
• Fluocortolone Trimethylacetate
• Fluocortolone pivalate
• Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,21-dihydroxy-16α-methyl-, 21-pivalate

Fluocortolone Pivalate

CAS: 29205-06-9

Formula: C₂₇H₃₇FO₅

Color and Shape: White To Off-White Solid

Molecular weight: 460.59

Ref: 4Z-F-071001

Fluocortolone Pivalate

Controlled Product

CAS: 29205-06-9

Formula: C₂₇H₃₇FO₅

Color and Shape: Neat

Molecular weight: 460.58

Ref: TR-F500520

Fluocortolone pivalate

Controlled Product

CAS: 29205-06-9

Fluocortolone pivalate is a combination drug preparation that contains the corticosteroid fluocortolone and the anti-inflammatory agent pivalic acid. Fluocortolone pivalate is used to treat inflammatory skin disorders, such as atopic dermatitis, psoriasis, or eczema. The formulation has been shown to be effective in treating various autoimmune diseases and infectious diseases such as t-cell lymphomas. Fluocortolone pivalate also has long-term efficacy, with a duration of action of up to 3 weeks after discontinuation of treatment. It has been shown to be more effective than untreated group for symptoms such as itching and redness. However, this medication can cause negative drug interactions with other drugs including oral contraceptives, warfarin, and digoxin.

Formula: C₂₇H₃₇FO₅

Purity: Min. 95%

Molecular weight: 460.58 g/mol

Ref: 3D-FF31664

Fluocortolone pivalate

CAS: 29205-06-9

Fluocortolone pivalate

Formula: C₂₇H₃₇FO₅

Purity: 98.0%

Color and Shape: White

Molecular weight: 460.2625

Ref: 47-162