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CAS 29205-06-9

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Fluocortolone pivalate

Description:
Fluocortolone pivalate is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatological and systemic treatments. It is characterized by its ability to modulate the immune response and reduce inflammation, making it effective in treating various skin conditions and autoimmune disorders. The substance is a derivative of fluocortolone, which is a potent glucocorticoid, and the pivalate ester enhances its lipophilicity, improving skin penetration and bioavailability. Fluocortolone pivalate typically exhibits a high affinity for glucocorticoid receptors, leading to a range of biological effects, including the inhibition of pro-inflammatory cytokines and the promotion of anti-inflammatory pathways. It is usually formulated in topical preparations, such as creams or ointments, and is administered to minimize systemic exposure while maximizing local therapeutic effects. As with other corticosteroids, its use may be associated with potential side effects, including skin atrophy and local irritation, particularly with prolonged use. Proper medical guidance is essential for its application to ensure efficacy and safety.
Formula:C27H37FO5
InChI:InChI=1S/C27H37FO5/c1-14-9-17-16-11-19(28)18-10-15(29)7-8-26(18,5)23(16)20(30)12-27(17,6)22(14)21(31)13-33-24(32)25(2,3)4/h7-8,10,14,16-17,19-20,22-23,30H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,22-,23-,26+,27+/m1/s1
InChI key:InChIKey=XZBJVIQXJHGUBE-HZMVJJPJSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(C[C@@H](C)[C@@H]2C(COC(C(C)(C)C)=O)=O)[H]
Synonyms:
  • (6Alpha,11Beta,16Alpha)-6-Fluoro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 2,2-Dimethylpropanoate
  • (6α,11β,16α)-21-(2,2-Dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 20380-10-3
  • 6α-Fluoro-11β-hydroxy-21-trimethylacetoxy-16α-methylpregna-1,4-diene-3,20-dione
  • Flucortolone pivalate
  • Fluocortolone 21-trimethylacetate
  • Fluocortolone Trimethylacetate
  • Fluocortolone pivalate
  • Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6-fluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-
  • Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,21-dihydroxy-16α-methyl-, 21-pivalate
Found 11 products.