CAS 292171-04-1

Abcb1

Description:

Abcb1, also known as P-glycoprotein or multidrug resistance protein 1 (MDR1), is a membrane-bound protein that plays a crucial role in the transport of various substances across cellular membranes. It is encoded by the ABCB1 gene and is part of the ATP-binding cassette (ABC) transporter family. This protein is primarily involved in the efflux of drugs and xenobiotics, contributing to the phenomenon of multidrug resistance in cancer cells. Abcb1 is characterized by its ability to transport a wide range of substrates, including anticancer agents, antibiotics, and other therapeutic compounds, thereby influencing their bioavailability and efficacy. Its expression is found in various tissues, including the intestines, liver, and blood-brain barrier, which affects drug absorption, distribution, and elimination. The modulation of Abcb1 activity is of significant interest in pharmacology and drug development, as it can impact treatment outcomes in various diseases, particularly in oncology. Understanding the characteristics and mechanisms of Abcb1 is essential for optimizing drug therapies and overcoming resistance in clinical settings.

Formula: C14H21N3O5

InChI: InChI=1S/C14H21N3O5/c1-9(18)16-6-2-4-10(16)13(20)15-8-12(19)17-7-3-5-11(17)14(21)22/h10-11H,2-8H2,1H3,(H,15,20)(H,21,22)/t10-,11-/m0/s1

InChI key: GSBMVIVQPLOJGL-QWRGUYRKSA-N

SMILES: CC(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)O

Ac-Pro-Gly-Pro-OH

CAS: 292171-04-1

AcPGP (N-α-PGP), an extracellular matrix (ECM)-derived CXC receptor ligand, is generated during airway inflammation. The activity of AcPGP links degradation of ECM with neutrophil recruitment in airway inflammation. AcPGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases.

Formula: C₁₄H₂₁N₃O₅

Purity: 97.1%

Color and Shape: White

Molecular weight: 311.34

Ref: 01-4051879

Ac-Pro-Gly-Pro-OH

CAS: 292171-04-1

Ac-Pro-Gly-Pro-OH can be used as a CXCR2 agonist with bactericidal and anti-inflammatory activity for the study of sepsis and lung inflammation.

Formula: C₁₄H₂₁N₃O₅

Purity: 98.32%

Color and Shape: White Solid

Molecular weight: 311.33

Ref: TM-T76662

Ac-Pro-Gly-Pro-OH

CAS: 292171-04-1

Ac-Pro-Gly-Pro-OH

Formula: C₁₄H₂₁N₃O₅

Purity: ≥98%

Molecular weight: 311.33

Ref: 54-BUP03063

Ac-Pro-Gly-Pro-OH

CAS: 292171-04-1

Formula: C₁₄H₂₁N₃O₅

Molecular weight: 311.3336

Ref: IN-DA00C1F7

Semax Impurity 2 (Ac-Pro-Gly-Pro-OH)

CAS: 292171-04-1

Formula: C₁₄H₂₁N₃O₅

Molecular weight: 311.34

Ref: 4Z-PS-268003

Ac-Pro-Gly-Pro-OH

CAS: 292171-04-1

Ac-Pro-Gly-Pro-OH is a protein that has been shown to inhibit the multidrug efflux pump, P-glycoprotein. It also inhibits p-gp, which is a transporter protein in the gut that helps remove toxic substances from the body. Ac-Pro-Gly-Pro-OH was shown to be an active inhibitor of polymerase chain reaction (PCR) for DNA samples obtained from cancer patients. Ac-Pro-Gly-Pro-OH may be used as a p-gp inhibitor in the treatment of bowel diseases and squamous cell carcinomas.

Formula: C₁₄H₂₁N₃O₅

Purity: Min. 95%

Molecular weight: 311.33 g/mol

Ref: 3D-FA109833