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CAS 2933935-13-6

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  • KRASG12D-IN-5
    Targetmol
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    KRASG12D-IN-5

    CAS:
    KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.
    Formula:C34H31F5N6O2
    Color and Shape:Solid
    Molecular weight:650.64

    Ref: TM-T211223

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