CAS 2941104-53-4

Formula: C26H23F2N3O6

InChI: InChI=1S/C26H23F2N3O6/c1-14(13-32)36-24-10-16-20(11-23(24)35-3)30-7-5-22(16)37-25-18(27)8-15(9-19(25)28)31-26(33)17-12-29-6-4-21(17)34-2/h4-12,14,32H,13H2,1-3H3,(H,31,33)/t14-/m0/s1

InChI key: GCIKJNJUNJFZPR-AWEZNQCLSA-N

SMILES: C[C@@H](CO)OC1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3F)NC(=O)C4=C(C=CN=C4)OC)F

KIN-8741

CAS: 2941104-53-4

KIN-8741 is a highly selective and orally active Type IIb c-Met inhibitor. It exhibits broad-spectrum activity against c-Met kinase mutations. KIN-8741 demonstrates antitumor activity in non-small cell lung cancer models with MET gene amplification and exon 14 deletion. It is applicable in research on c-Met-driven cancers, particularly advanced tumors harboring MET exon 14 skipping mutations and acquired resistance mutations.

Formula: C₂₆H₂₃F₂N₃O₆

Color and Shape: Solid

Molecular weight: 511.47

Ref: TM-T211183