CAS 294891-81-9

Formula: C22H18N2O4

InChI: InChI=1S/C22H18N2O4/c25-20(13-15-7-2-1-3-8-15)23-17-10-6-9-16(14-17)21(26)24-19-12-5-4-11-18(19)22(27)28/h1-12,14H,13H2,(H,23,25)(H,24,26)(H,27,28)

InChI key: OBGIRQUECFHUEY-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)CC(=O)NC2=CC=CC(=C2)C(=O)NC3=CC=CC=C3C(=O)O

BML-286

CAS: 294891-81-9

BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.

Formula: C₂₂H₁₈N₂O₄

Purity: 99.3%

Color and Shape: Solid

Molecular weight: 374.39

Ref: TM-T200419

BML-286

CAS: 294891-81-9

Purity: 95.0%

Ref: IN-DA00C2ZB

BML-286

CAS: 294891-81-9

BML-286

Formula: C₂₂H₁₈N₂O₄

Purity: ≥98%

Molecular weight: 374.39

Ref: 54-BUP00605

BML-286

Controlled Product

CAS: 294891-81-9

Applications A small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways.
References Grandy, D. et al.: J. Biol. Chem., 284, 24 (2009);

Formula: C₂₂H₁₈N₂O₄

Color and Shape: Neat

Molecular weight: 374.389

Ref: TR-B595870

BML 286

CAS: 294891-81-9

Inhibits dishevelled (Dvl)-PDZ domain interaction; affects Wnt signaling pathway

Formula: C₂₂H₁₈N₂O₄

Purity: Min. 95%

Molecular weight: 374.39 g/mol

Ref: 3D-FB18841