CAS 2966924-24-1

KRASG12C IN-18

CAS: 2966924-24-1

KRASG12C IN-18 is an orally active covalent inhibitor of KRASG12C, achieving complete covalent binding to KRASG12C in both GDP- and GMPPNP-bound states. It exhibits significant antiproliferative activity against KRASG12C and its resistant mutations (including KRASG12C/R68S) with an IC50 in the low nanomolar range. KRASG12C IN-18 demonstrates notable in vivo efficacy in KRASG12C-driven solid tumors and KRASG12C/R68S xenograft models, making it applicable for colorectal adenocarcinoma research.

Formula: C₃₇H₃₂F₄N₆O₂

Molecular weight: 668.7

Ref: TM-T214145