CAS 2975172-98-4

Formula: C26H29FN8OS2

InChI: InChI=1S/C26H29FN8OS2/c1-33-7-9-34(10-8-33)20-4-3-18(11-21(20)36-2)31-25-29-12-19(22-13-28-16-37-22)24(32-25)23-14-30-26(38-23)35-6-5-17(27)15-35/h3-4,11-14,16-17H,5-10,15H2,1-2H3,(H,29,31,32)/t17-/m0/s1

InChI key: KASJGKMQWZOSTG-KRWDZBQOSA-N

SMILES: CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC=C(C(=N3)C4=CN=C(S4)N5CC[C@@H](C5)F)C6=CN=CS6)OC

WEE1-IN-11

CAS: 2975172-98-4

WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC₅₀ of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC₅₀ values of 93.9, 34.5, 86.7, 23.1, and 85 nM.

Formula: C₂₆H₂₉FN₈OS₂

Color and Shape: Solid

Molecular weight: 552.69

Ref: TM-T200924