CAS 29767-20-2: Teniposide

Description: Teniposide, with the CAS number 29767-20-2, is a semisynthetic derivative of podophyllotoxin, primarily used as an antineoplastic agent in cancer therapy. It functions by inhibiting topoisomerase II, an enzyme crucial for DNA replication and repair, thereby inducing DNA damage and apoptosis in rapidly dividing cancer cells. Teniposide is typically administered intravenously and is indicated for the treatment of various malignancies, including certain types of leukemia and solid tumors. The compound is characterized by its complex chemical structure, which includes a phenolic moiety and an ether linkage, contributing to its biological activity. It is generally soluble in organic solvents but has limited solubility in water. Side effects may include myelosuppression, gastrointestinal disturbances, and hypersensitivity reactions. Due to its potent effects and potential toxicity, teniposide is usually prescribed under strict medical supervision, with careful monitoring of the patient's response and side effects during treatment.

Formula: C₃₂H₃₂O₁₃S

InChI: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1

InChI key: InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N

SMILES: O=C1OCC2C(OC3OC4COC(OC4C(O)C3O)C=5SC=CC5)C6=CC=7OCOC7C=C6C(C8=CC(OC)=C(O)C(OC)=C8)C12

Synonyms:

• (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• EPT
• Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
• Epipodophyllotoxin, 4′-demethyl-, 9-(4,6-O-2-thenylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
• Nsc 122819
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• S 122819
• Teniposid
• Teniposide
• Teniposido
• Tenoposide
• Vehem
• Vehem-Sandoz
• Vm 26
• Vumon
• 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-beta-d-glucopyranoside)
• 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophylloto
• (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucoside
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)hexopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophyllot
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl (4xi)-4,6-O-(thiophen-2-ylmethylidene)-beta-D-xylo-hexopyranoside
• 3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-bata-d-glucopyranoside.
• 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucosid
• 4’-demethylepipodophyllotoxin-beta-d-thenylidineglucoside
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-

Teniposide

CAS: 29767-20-2

• Formula: C₃₂H₃₂O₁₃S
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystaline
• Molecular weight: 656.66

5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

CAS: 29767-20-2

• Formula: C₃₂H₃₂O₁₃S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 656.6537

Teniposide

CAS: 29767-20-2

Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming …

• Formula: C₃₂H₃₂O₁₃S
• Purity: 97.70% - 99.45%
• Color and Shape: White Or Off-White Crystalline Powder
• Molecular weight: 656.65

(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1

CAS: 29767-20-2

• Purity: 98%
• Molecular weight: 656.65g/mol

Teniposide

CAS: 29767-20-2

• Formula: C₃₂H₃₂O₁₃S
• Color and Shape: White To Off-White Solid
• Molecular weight: 656.66

Teniposide

CAS: 29767-20-2

• Formula: C₃₂H₃₂O₁₃S
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 656.65

Teniposide - Bio-X ™

CAS: 29767-20-2

Teniposide is a cytotoxic drug that is used in the treatment of refractory childhood acute …

• Formula: C₃₂H₃₂O₁₃S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 656.65 g/mol

Teniposide

CAS: 29767-20-2

Type II topoisomerase inhibitor

• Formula: C₃₂H₃₂O₁₃S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 656.65 g/mol

Teniposide

CAS: 29767-20-2

Stability Hygroscopic Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic. References Stahlen, H., Eur. J. Cancer, …

• Formula: C₃₂H₃₂O₁₃S
• Color and Shape: Neat
• Molecular weight: 656.65

Teniposide (PLANNED TO BE DISCONTINUED)

CAS: 29767-20-2

Other glycosides, natural or reproduced by synthesis, a

• Formula: C₃₂H₃₂O₁₃S
• Color and Shape: Powder
• Molecular weight: 656.15636