CAS 29767-20-2

Teniposide

Description:

Teniposide, with the CAS number 29767-20-2, is a semisynthetic derivative of podophyllotoxin, primarily used as an antineoplastic agent in cancer therapy. It functions by inhibiting topoisomerase II, an enzyme crucial for DNA replication and repair, thereby inducing DNA damage and apoptosis in rapidly dividing cancer cells. Teniposide is typically administered intravenously and is indicated for the treatment of various malignancies, including certain types of leukemia and solid tumors. The compound is characterized by its complex chemical structure, which includes a phenolic moiety and an ether linkage, contributing to its biological activity. It is generally soluble in organic solvents but has limited solubility in water. Side effects may include myelosuppression, gastrointestinal disturbances, and hypersensitivity reactions. Due to its potent effects and potential toxicity, teniposide is usually prescribed under strict medical supervision, with careful monitoring of the patient's response and side effects during treatment.

Formula: C₃₂H₃₂O₁₃S

InChI: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1

InChI key: InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@@H](OC5)C6=CC=CS6)[H])[H])[C@]2(CO1)[H])=CC7=C(C3)OCO7)C8=CC(OC)=C(O)C(OC)=C8)[H]

Synonyms:

• (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• EPT
• Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
• Epipodophyllotoxin, 4′-demethyl-, 9-(4,6-O-2-thenylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
• Nsc 122819
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• S 122819
• Teniposid
• Teniposide
• Teniposido
• Tenoposide
• Vehem
• Vehem-Sandoz
• Vm 26
• Vumon
• 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-beta-d-glucopyranoside)
• 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophylloto
• (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucoside
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)hexopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4’-demethyl1-o-(4,6-o,o-(2-thenylidene)-beta-d-glucopyranosyl)epipodophyllot
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl (4xi)-4,6-O-(thiophen-2-ylmethylidene)-beta-D-xylo-hexopyranoside
• 3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
• 4’-demethylepipodophyllotoxin9-(4,6-o-2-thenylidene-bata-d-glucopyranoside.
• 4’-demethyl-epipodophyllotoxin-beta-d-thenylidene-glucosid
• 4’-demethylepipodophyllotoxin-beta-d-thenylidineglucoside

Teniposide

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 656.66

Ref: 3B-T3109

Teniposide

CAS: 29767-20-2

(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-(thiophen-2-yl)hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

Formula: C₃₂H₃₂O₁₃S

Purity: 98%

Molecular weight: 656.65

Ref: IN-DG152568

Teniposide

CAS: 29767-20-2

Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and

Formula: C₃₂H₃₂O₁₃S

Purity: 97.7% - 99.45%

Color and Shape: Solid

Molecular weight: 656.65

Ref: TM-T1523

5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 656.6537

Ref: IN-DA00I5IB

Teniposide

CAS: 29767-20-2

Teniposide

Formula: C₃₂H₃₂O₁₃S

Purity: 98%

Molecular weight: 656.65

Ref: 54-OR1026151

Teniposide

CAS: 29767-20-2

Teniposide

Formula: C₃₂H₃₂O₁₃S

Purity: ≥95%

Molecular weight: 656.65

Ref: 54-BUP13995

Teniposide

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 656.65

Ref: 7W-GP2668

Teniposide

CAS: 29767-20-2

Formula: C₃₂H₃₂O₁₃S

Color and Shape: White To Off-White Solid

Molecular weight: 656.66

Ref: 4Z-T-521

Teniposide - Bio-X ™

CAS: 29767-20-2

Teniposide is a cytotoxic drug that is used in the treatment of refractory childhood acute lymphoblastic leukemia. It has antitumour activity. It is a type II topoisomerase inhibitor. This drug inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

Formula: C₃₂H₃₂O₁₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 656.65 g/mol

Ref: 3D-BT164452

Teniposide

CAS: 29767-20-2

Type II topoisomerase inhibitor

Formula: C₃₂H₃₂O₁₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 656.65 g/mol

Ref: 3D-FT09381

TENIPOSIDE

CAS: 29767-20-2

Purity: 98%

Molecular weight: 656.6599731

Ref: 10-F792701

Teniposide

Controlled Product

CAS: 29767-20-2

Stability Hygroscopic
Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic.
References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),

Formula: C₃₂H₃₂O₁₃S

Color and Shape: Neat

Molecular weight: 656.65

Ref: TR-T018400

Teniposide (DISCONTINUED)

CAS: 29767-20-2

Other glycosides, natural or reproduced by synthesis, a

Formula: C₃₂H₃₂O₁₃S

Color and Shape: Powder

Molecular weight: 656.15636

Ref: 45-1643736