CAS 29782-68-1

Silydianin

Description:

Silydianin is a flavonolignan compound primarily derived from the milk thistle plant, Silybum marianum. It is one of the active constituents of silymarin, a complex of flavonoids known for their hepatoprotective properties. Silydianin exhibits antioxidant activity, which helps in neutralizing free radicals and reducing oxidative stress in liver cells. This compound is often studied for its potential therapeutic effects in liver diseases, including hepatitis and cirrhosis, as it may promote liver regeneration and improve liver function. Additionally, silydianin has been investigated for its anti-inflammatory and cytoprotective effects, contributing to its overall health benefits. The substance is typically characterized by its solubility in organic solvents and limited solubility in water, which is common for many flavonoids. Its pharmacological properties and safety profile make it a subject of interest in herbal medicine and dietary supplements aimed at supporting liver health.

Formula: C₂₅H₂₂O₁₀

InChI: InChI=1S/C25H22O10/c1-33-16-4-9(2-3-14(16)27)18-11-7-12(20-13(18)8-34-25(20,32)24(11)31)23-22(30)21(29)19-15(28)5-10(26)6-17(19)35-23/h2-7,11,13,18,20,22-23,26-28,30,32H,8H2,1H3/t11-,13-,18+,20+,22+,23-,25-/m1/s1

InChI key: InChIKey=CYGIJEJDYJOUAN-JSGXPVSSSA-N

SMILES: O[C@@]12[C@@]3([C@@]([C@H]([C@@](C=C3[C@H]4OC=5C(C(=O)[C@@H]4O)=C(O)C=C(O)C5)(C1=O)[H])C6=CC(OC)=C(O)C=C6)(CO2)[H])[H]

Synonyms:

• (+)-2,3alpha,3aalpha,7a-Tetrahydro-7aalpha-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3alpha,5,7-trihydroxy-4-oxo-2beta-chromanyl)-3,6-methanobenzofuran-7(6alphaH)-one
• (3R,3aR,6R,7aR)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one
• (3R,3aR,6R,7aR,8R)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-[(2R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• 3,6-Methanobenzofuran-7(6H)-one, 4-(3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, [3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-
• 3,6-Methanobenzofuran-7(6H)-one, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, (3R,3aR,6R,7aR,8R)-
• 3,6-Methanobenzofuran-7(6αH)-one, 2,3α,3aα,7a-tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-, (+)-
• 7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)-2,3,3a,7a-tetrahydro-3,6-methano-1-benzofuran-7(6H)-one
• Silidianin [INN]
• Silidianina
• Silidianina [INN-Spanish]
• Silidianine
• Silidianine [INN-French]
• Silidianinum
• Silidianinum [INN-Latin]

Silydianin

CAS: 29782-68-1

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₂₅H₂₂O₁₀

Color and Shape: Yellow Powder

Molecular weight: 482.4

Ref: 45-1612641

Silydianin

CAS: 29782-68-1

Silydianin

Formula: C₂₅H₂₂O₁₀

Purity: ≥95%

Molecular weight: 482.44

Ref: 54-BUP02913

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Purity: 95%

Color and Shape: Solid

Molecular weight: 482.4362

Ref: IN-DA00BE5C

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Purity: ≥ 98.0%

Color and Shape: Off-white powder

Molecular weight: 482.44

Ref: 7W-GY6531

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

CAS: 29782-68-1

(3R,3Ar,6R,7Ar,8R)-7A-Hydroxy-8-(4-Hydroxy-3-Methoxyphenyl)-4-((2R,3R)-3,5,7-Trihydroxy-4-Oxochroman-2-Yl)-3,3A,6,7A-Tetrahydro-3,6-Methanobenzofuran-7(2H)-One

Formula: C₂₅H₂₂O₁₀

Purity: 95%

Molecular weight: 482.44

Ref: 54-OR1023990

Silydianin (Standard)

CAS: 29782-68-1

Silydianin (Standard) is a reference standard for research and analysis in studies involving Silydianin. Silydianin (Silidianin) exerts inhibition of UGT in human liver. Silydianin exerts inhibition of OATP1B1, OATP1B3 (unknown origin) expressed in HEK293 cells. Silydianin exerts inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells.

Formula: C₂₅H₂₂O₁₀

Color and Shape: Solid

Molecular weight: 482.44

Ref: TM-TMSM-2805

Silydianin

CAS: 29782-68-1

Silydianin, an active constituent of Silybium marianum, has inhibitory effect on on the in vitro production and release of oxidative products. Silydianin has possible antiinflammatory activity, which regulates caspase-3 activation, affects cell membranes and acts as a free radical scavenger.

Formula: C₂₅H₂₂O₁₀

Purity: 95%~99%

Molecular weight: 482.441

Ref: BP-BP1307

Silydianin

Controlled Product

CAS: 29782-68-1

Applications Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.
References Zlelinska-Przyyjemska, M., et al.: Phytother. Res., 20, 115 (2006); Milan, M., et al.L Anal. Chimica. Acta., 486, 125 (2003); Liu, Y.Z., et al.: Chin. Herb. Med., 4, 237 (2012);

Formula: C₂₅H₂₂O₁₀

Color and Shape: Neat

Molecular weight: 482.44

Ref: TR-S465890

Silydianin

CAS: 29782-68-1

Silydianin inhibits UGT, OATP1B1, OATP1B3 in HEK293 cells, and OATP2B1 in MDCK2 cells.

Formula: C₂₅H₂₂O₁₀

Purity: 98.01% - 98.56%

Color and Shape: Solid

Molecular weight: 482.44

Ref: TM-T3880

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Molecular weight: 482.45

Ref: 4Z-S-398

Silydianin

CAS: 29782-68-1

Oxygen-heterocyclic compound

Formula: C₂₅H₂₂O₁₀

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 482.44

Ref: 5G-89282

Silydianin

CAS: 29782-68-1

Silydianin is a flavonolignan compound, which is derived from the seeds of the milk thistle plant, Silybum marianum. Its primary mode of action involves antioxidant properties and inhibition of lipid peroxidation. Silydianin contributes to the stabilization of cell membranes, thereby preventing toxins from entering liver cells, and also stimulates the activity of ribosomal RNA, promoting liver cell regeneration.

Formula: C₂₅H₂₂O₁₀

Purity: Min. 95.0 Area-%

Molecular weight: 482.44 g/mol

Ref: 3D-FS42773

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Molecular weight: 482.4

Ref: BE-RMT17477

Silydianin

CAS: 29782-68-1

Formula: C₂₅H₂₂O₁₀

Molecular weight: 482.4

Ref: BE-RMCS100013

Silydianin

CAS: 29782-68-1

(3R,3aR,6R,7aR,8R)-7a-Hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-((2R,3R)-3,5,7-trihydroxy-4-oxochroman-2-yl)-3,3a,6,7a-tetrahydro-3,6-methanobenzofuran-7(2H)-one

Formula: C₂₅H₂₂O₁₀

Purity: 95%

Molecular weight: 482.44

Ref: IN-DG151185