CAS 298220-99-2

8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Description:

8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, identified by its CAS number 298220-99-2, is a chemical compound that belongs to a class of heterocyclic organic compounds. It features a complex bicyclic structure that incorporates both a piperidine moiety and halogen substituents, specifically chlorine and fluorine. This compound is characterized by its potential pharmacological properties, often investigated for its role in medicinal chemistry, particularly in the development of therapeutic agents targeting neurological disorders. The presence of the piperidine ring suggests possible interactions with neurotransmitter systems, while the halogen atoms may influence its lipophilicity and biological activity. Its unique structural features contribute to its specificity and efficacy in biological applications. As with many compounds in this category, understanding its solubility, stability, and reactivity is crucial for its practical use in research and development. Safety and handling precautions are essential due to the presence of halogens and the potential for biological activity.

Formula: C₁₉H₂₀ClFN₂

Synonyms:

• 8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 4-[(11RS)-8-chloro-11-fluoro-6,11-dihydro-5H-benzo [5,6] cyclohepta [1,2-b]pyridin-11-yl]piperidine
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-
• 11-Fluoro Desloratadine HCl
• 11-Fluoro Dihydrodesloratadine
• Desloratadine Impurity 1/Desloratadine EP Impurity A
• 8-chloro-11-fluoro-11-piperidin-4-yl-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
• 8-chloro-11-fluoro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 11-Fluoro Desloratadine
• Desloratadine EP Impurity A

Desloratadine EP Impurity A DiHCl (11-Fluoro Desloratadine DiHCl)

CAS: 2250242-44-3, 298220-99-2

Formula: C₁₉H₂₀ClFN₂·2HCl

Color and Shape: White To Off-White Solid

Molecular weight: 330.83 2*36.46

Ref: 4Z-L-1039

(11RS)-8-Chloro-11-fluoro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

CAS: 298220-99-2

Color and Shape: Neat

Ref: 86-MM3528.01

Desloratadine EP Impurity A

CAS: 298220-99-2

Formula: C₁₉H₂₀ClFN₂

Molecular weight: 330.83

Ref: ST-EA-CP-D15001

11-Fluoro Desloratadine

Controlled Product

CAS: 298220-99-2

Impurity Desloratadine EP Impurity A
Applications 11-Fluoro Desloratadine (Desloratadine EP Impurity A) is a fluorine substituted benzocycloheptapyridine derivative with antihistaminic activity.
References Zheng, J. et al.: J. Pharmac. Biomed. Anal., 51, 146 (2010);

Formula: C₁₉H₂₀ClFN₂

Color and Shape: Neat

Molecular weight: 330.83

Ref: TR-F590900

11-Fluoro desloratadine

CAS: 298220-99-2

11-Fluoro desloratadine is a metabolite of the antihistamine, loratadine. It has shown to be an analytical standard for HPLC, and impurity standard for pharmacopoeia. 11-Fluoro desloratadine is typically synthesized by reacting loratadine with fluorinating reagent such as N-fluorosuccinimide (NFSI) in the presence of a base catalyst such as sodium methoxide. 11-Fluoro desloratadine is also found in breast milk at concentrations of up to 1.2% of total loratadine concentration, which has been attributed to incomplete metabolism or passive transfer from mother to child.

Formula: C₁₉H₂₀N₂ClF

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 330.83 g/mol

Ref: 3D-IF46257