CAS 3024545-79-4

CDK7-IN-26

Formula: C₂₂H₂₂FN₆OPS

InChI: InChI=1S/C22H22FN6OPS/c1-31(2,30)20-12(8-24)3-4-15-16(11-26-18(15)20)19-21-17(5-6-32-21)28-22(29-19)27-14-7-13(23)9-25-10-14/h3-6,11,13-14,25-26H,7,9-10H2,1-2H3,(H,27,28,29)/t13-,14-/m0/s1

InChI key: DHZKWPMYADCRCR-KBPBESRZSA-N

SMILES: CP(=O)(C)C1=C(C=CC2=C1NC=C2C3=NC(=NC4=C3SC=C4)N[C@H]5C[C@@H](CNC5)F)C#N

Synonyms:

• CDK7-IN-26

CDK7-IN-26

CAS: 3024545-79-4

CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.

Formula: C₂₂H₂₂FN₆OPS

Color and Shape: Solid

Molecular weight: 468.49

Ref: TM-T208352