CAS 3037776-73-8

Formula: C36H44ClN9O5S

InChI: InChI=1S/C36H44ClN9O5S/c1-24-7-6-10-27(37)33(24)44-35(49)29-23-40-36(52-29)43-30-22-31(42-25(2)41-30)46-15-13-45(14-16-46)17-20-51-32(47)11-18-50-19-12-39-34(48)28(38)21-26-8-4-3-5-9-26/h3-10,22-23,28H,11-21,38H2,1-2H3,(H,39,48)(H,44,49)(H,40,41,42,43)/t28-/m0/s1

InChI key: VJFIUIXDGOFPOP-NDEPHWFRSA-N

SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCOC(=O)CCOCCNC(=O)[C@H](CC5=CC=CC=C5)N

Phe-PEG1-Dasa

CAS: 3037776-73-8

Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader with a DC50 of 1.56 nM. It employs a single amino acid (Phe) as an E3 ligase ligand, leveraging the N-end rule pathway to induce target protein degradation, thereby significantly reducing its molecular size, earning the name mini-PROTAC. Phe-PEG1-Dasa markedly inhibits the proliferation of K562 cells and is applicable in leukemia research.

Formula: C₃₆H₄₄ClN₉O₅S

Molecular weight: 750.32

Ref: TM-T217162