CAS 304-20-1

Hydralazine hydrochloride

Description:

Hydralazine hydrochloride is a pharmaceutical compound primarily used as an antihypertensive agent to manage high blood pressure. It is classified as a vasodilator, which means it works by relaxing the blood vessels, thereby reducing the workload on the heart. The chemical formula for hydralazine hydrochloride is C8H8N4·HCl, indicating it contains a hydrazine moiety, which is essential for its biological activity. This compound is typically administered orally or intravenously and is known for its rapid onset of action. Hydralazine hydrochloride is characterized by its white to off-white crystalline appearance and is soluble in water, making it suitable for various formulations. Common side effects may include headache, palpitations, and gastrointestinal disturbances. It is important to monitor patients for potential adverse reactions, such as lupus-like syndrome, especially with long-term use. Overall, hydralazine hydrochloride plays a significant role in the management of hypertension, particularly in cases where other treatments may not be effective.

Formula: C₈H₈N₄·ClH

InChI: InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H

InChI key: InChIKey=ZUXNZUWOTSUBMN-UHFFFAOYSA-N

SMILES: N(N)=C1C=2C(C=NN1)=CC=CC2.Cl

Synonyms:

• (Phthalazin-1-yl)hydrazine hydrochloride
• 1(2H)-Phthalazinone hydrazone
• 1(2H)-Phthalazinone, hydrazone, monohydrochloride
• 1-Hydrazinophthalazine hydrochloride
• 1-Hydrazinophthalazine monohydrochloride
• 1-Hydrazinylphthalazine
• 1-Hydrazinylphthalazine Hydrochloride (1:1)
• 1-Hydrazinylphthalazine hydrochloride
• Apresoline hydrochloride
• Apulon
• Hydralazine chloride
• Hydralazine hcl
• Hydralazine monohydrochloride
• Lopres
• Phthalazine, 1-hydrazino-, monohydrochloride
• Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)

1-Hydrazinophthalazine Hydrochloride

CAS: 304-20-1, 86-54-4

Formula: C₈H₈N₄·HCl

Purity: >99.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 196.64

Ref: 3B-H0409

1-Hydrazinophthalazine hydrochloride, 98%

CAS: 304-20-1

A monoamine oxidase inhibitor1-Hydrazinophthalazine hydrochloride is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumor suppressor genes. It acts as a non-selective MAO-A/B inhibitor and semicarbazide sensitive amine oxidase inhibitor. Further, it serves as

Formula: C₈H₈N₄•HCl

Purity: 98%

Color and Shape: White to pale cream, Powder or crystals or crystalline powder

Molecular weight: 196.64

Ref: 02-B22995

HYDRALAZINE HYDROCHLORIDE CRS

CAS: 304-20-1

HYDRALAZINE HYDROCHLORIDE CRS

Formula: C₈H₉ClN₄

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 196.6369

Ref: 41-H1120000

Hydralazine Hydrochloride

CAS: 304-20-1

Hydralazine hydrochloride

Formula: C₈H₈N₄·HCl

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 160.0749

Ref: 45-1313006

Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)

CAS: 304-20-1

Formula: C₈H₉ClN₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 196.6369

Ref: IN-DA003006

Hydralazine hydrochloride

CAS: 304-20-1

Hydralazine hydrochloride, an antihypertensive phthalazine, induces vasodilation and may inhibit tumor DNA methylation.

Formula: C₈H₉ClN₄

Purity: 99.85% - 99.86%

Color and Shape: Yellow Crystals White Crystalline Solid

Molecular weight: 196.64

Ref: TM-T1613

Hydralazine hydrochloride

CAS: 304-20-1

Hydralazine hydrochloride

Purity: ≥98%

Molecular weight: 196.64g/mol

Ref: 54-BUP17906

Hydralazine hydrochloride

CAS: 304-20-1

Formula: C₈H₈N₄HCl

Molecular weight: 196.64

Ref: 7W-GL6824

Hydralazine HCl (Dihydralazine EP Impurity C HCl)

CAS: 304-20-1

Formula: C₈H₈N₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 160.18 36.46

Ref: 4Z-H-135

1-hydrazinyl-Phthalazine hydrochloride

CAS: 304-20-1

1-hydrazinyl-Phthalazine hydrochloride

Purity: 98%

Molecular weight: 196.64g/mol

Ref: 54-OR1009501

Hydralazine hydrochloride

CAS: 304-20-1

Formula: C₈H₈N₄·ClH

Color and Shape: Off-White

Molecular weight: 196.64

Ref: 04-C14219100

Hydralazine Hydrochloride

Controlled Product

CAS: 304-20-1

Applications Hydralazine is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumour suppressor genes (1,2,3). It is also a non-selective MAO-A/B inhibitor and a semicarbazide-sensitive amine oxidase inhibitor. Antihypertensive.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Siedlecki, P., et al.: J. Med. Chem. 49, 678 (2006) (2) Link, P., et al.: Cancer Res., 68, 9358 (2008) (3) Singh, N., et al.: ChemMedChem., 4, 792 (2009)

Formula: C₈H₈N₄·ClH

Color and Shape: Off-White

Molecular weight: 196.64

Ref: TR-H716531

1-Hydrazinylphthalazine hydrochloride

CAS: 304-20-1

Formula: C₈H₉ClN₄

Purity: 98%

Color and Shape: Solid, White to very pale yellow powder

Molecular weight: 196.64

Ref: 10-F236804

Hydralazine hydrochloride

CAS: 304-20-1

Hydralazine hydrochloride is a drug used to treat high blood pressure. It is an inhibitor of the enzyme phosphodiesterase, which leads to increased levels of cAMP and vasodilation in the lungs. Hydralazine hydrochloride has been shown to induce renal injury, specifically by inhibiting the synthesis of prostaglandins that protect the kidneys from damage. This drug can also cause cardiac effects such as tachycardia and arrhythmias. Hydralazine hydrochloride interacts with other drugs, including Candesartan cilexetil and other drugs that inhibit phosphodiesterase, leading to an increase in blood pressure. Hydralazine hydrochloride binds to guanine nucleotide-binding proteins (G proteins) on neural cells and increases the rate constant for G protein activation.

Formula: C₈H₉ClN₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 196.64 g/mol

Ref: 3D-FH23871