Product Information
- Hydralazine HCl, Apresoline
- (Phthalazin-1-yl)hydrazine hydrochloride
- 1(2H)-Phthalazinone hydrazone
- 1(2H)-Phthalazinone, hydrazone, monohydrochloride
- 1-Hydrazinophthalazine hydrochloride
- 1-Hydrazinophthalazine monohydrochloride
- 1-Hydrazinylphthalazine
- 1-Hydrazinylphthalazine Hydrochloride (1:1)
- 1-Hydrazinylphthalazine hydrochloride
- Apresoline hydrochloride
- See more synonyms
- Apulon
- Hydralazine chloride
- Hydralazine hcl
- Hydralazine monohydrochloride
- Lopres
- Phthalazine, 1-hydrazino-, monohydrochloride
- Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
Chemical properties
Technical inquiry about: TM-T1613 Hydralazine hydrochloride
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