CAS 305-03-3: Chlorambucil

Description: Chlorambucil is a synthetic alkylating agent primarily used in chemotherapy for the treatment of certain types of cancer, particularly chronic lymphocytic leukemia and lymphoma. It belongs to the class of nitrogen mustards and functions by interfering with DNA replication, ultimately leading to cell death. Chlorambucil is characterized by its ability to form covalent bonds with DNA, which disrupts the normal cellular processes. The compound is typically administered orally and is known for its relatively mild side effect profile compared to other chemotherapeutic agents, although it can still cause bone marrow suppression and gastrointestinal disturbances. Its chemical structure includes a chloroethyl group, which is essential for its alkylating activity. Chlorambucil is classified as a hazardous substance, requiring careful handling and monitoring during use. Due to its mechanism of action, it is also associated with potential long-term risks, including secondary malignancies. Overall, Chlorambucil remains an important therapeutic option in oncology, particularly for patients who may not tolerate more aggressive treatments.

Formula: C₁₄H₁₉Cl₂NO₂

InChI: InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI key: InChIKey=JCKYGMPEJWAADB-UHFFFAOYSA-N

SMILES: O=C(O)CCCC1=CC=C(C=C1)N(CCCl)CCCl

Synonyms:

• 4-(P-Bis(2-Chloroethyl)Aminophenyl)Butyric Acid
• 4-(P-Bis(Beta-Chloroethyl)Aminophenyl)Butyric Acid
• 4-(p-(N,N-Di-2-chloroethyl)aminophenyl)butyric acid
• 4-(p-N,N-Di-(beta-chloroethyl)aminophenyl)butyric acid
• 4-[4-[3-Chloro-1-(2-Chloroethyl)Propyl]Phenyl]Butanoic Acid
• 4-[Bis(2-Chloroethyl)Amino]Benzenebutanoic Acid
• 4-[Bis(2-chloroethyl)aminophenyl]butyric acid
• 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid
• 4-{4-[Bis(2-Chloroethyl)Amino]Phenyl}Butanoic Acid
• Ambochlorin
• Amboclorin
• Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
• Butanoic acid, 4-[bis(2-chloroethyl)amino]benzene
• Butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]-
• Cb 1348
• Cb l348
• Chloraminophen
• Chloraminophene
• Chlorbutin
• Chloroambucil
• Chlorobutin
• Chlorobutine
• Clorambucilo
• Ecloril
• Elcoril
• Gamma-(P-Bis(2-Chloroethyl)Aminophenyl)Butyric Acid
• Leukeran
• Leukeran Tablets
• Leukersan
• Leukoran
• Linfolizin
• Linfolysin
• Lympholysin
• N,N-Di-(2-chloroethyl)-gamma-(p-aminophenyl)butyric acid
• Nci 3088
• Nsc 3088
• Phenylbutyric acid nitrogen mustard
• γ-[p-Bis(2-chloroethyl)aminophenyl]butyric acid
• γ-[p-Di(2-chloroethyl)aminophenyl]butyric acid

Chlorambucil

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: >98.0%(GC)(T)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 304.21

Chlorambucil with impurity G CRS

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: Powder
• Molecular weight: 304.2122

Chlorambucil CRS

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: Powder
• Molecular weight: 304.2122

Chlorambucil

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: 99.4%
• Color and Shape: White Solid
• Molecular weight: 303.07928

Chlorambucil for system suitability CRS

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: Powder
• Molecular weight: 304.2122

Chlorambucil

CAS: 305-03-3

Aromatic amino-acids and their esters,other than those containing more than one kind of oxygen function …

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: White Off-White Granular Crystalline Powder Needles
• Molecular weight: 303.07928

Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 304.2122

Chlorambucil

CAS: 305-03-3

Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: 97.37% - 98.45%
• Color and Shape: Off-White Slightly Granular Powder Melting Point 65-69°C
• Molecular weight: 304.21

Chlorambucil

CAS: 305-03-3

• Purity: 98%
• Molecular weight: 304.21g/mol

Chlorambucil

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: ≥ 98.0% (anhydrous)
• Color and Shape: White to off-white crystalline powder
• Molecular weight: 304.21

Chlorambucil

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: Pale Yellow To Off-White Solid
• Molecular weight: 304.22

Chlorambucil-d8

CAS: 305-03-3

• Formula: C₁₄H₁₁D₈Cl₂NO₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 312.26

Chlorambucil, EP grade

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: ≤ 0.1% (HPLC)
• Color and Shape: White or almost white crystalline powder
• Molecular weight: 304.21

Chlorambucil

CAS: 305-03-3

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: Neat
• Molecular weight: 304.21

Chlorambucil

CAS: 305-03-3

Applications Chlorambucil is a alkylating agent that is used as an chemotherapy drug in the …

• Formula: C₁₄H₁₉Cl₂NO₂
• Color and Shape: Neat
• Molecular weight: 304.21

Chlorambucil

CAS: 305-03-3

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 304.2099914550781

Chlorambucil-d8

CAS: 305-03-3

• Formula: C₁₄D₈H₁₁Cl₂NO₂
• Color and Shape: Neat
• Molecular weight: 312.262

4-[Bis(2-chloroethyl)aminophenyl]butyric acid

CAS: 305-03-3

4-[Bis(2-chloroethyl)aminophenyl]butyric acid is a bicyclic heterocycle that has been shown to be toxic to human …

• Formula: C₁₄H₁₉Cl₂NO₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 304.21 g/mol