CAS 305-03-3
:Chlorambucil
Description:
Chlorambucil is a synthetic alkylating agent primarily used in chemotherapy for the treatment of certain types of cancer, particularly chronic lymphocytic leukemia and lymphoma. It belongs to the class of nitrogen mustards and functions by interfering with DNA replication, ultimately leading to cell death. Chlorambucil is characterized by its ability to form covalent bonds with DNA, which disrupts the normal cellular processes. The compound is typically administered orally and is known for its relatively mild side effect profile compared to other chemotherapeutic agents, although it can still cause bone marrow suppression and gastrointestinal disturbances. Its chemical structure includes a chloroethyl group, which is essential for its alkylating activity. Chlorambucil is classified as a hazardous substance, requiring careful handling and monitoring during use. Due to its mechanism of action, it is also associated with potential long-term risks, including secondary malignancies. Overall, Chlorambucil remains an important therapeutic option in oncology, particularly for patients who may not tolerate more aggressive treatments.
Formula:C14H19Cl2NO2
InChI:InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChI key:InChIKey=JCKYGMPEJWAADB-UHFFFAOYSA-N
SMILES:N(CCCl)(CCCl)C1=CC=C(CCCC(O)=O)C=C1
Synonyms:- 4-(P-Bis(2-Chloroethyl)Aminophenyl)Butyric Acid
- 4-(P-Bis(Beta-Chloroethyl)Aminophenyl)Butyric Acid
- 4-(p-(N,N-Di-2-chloroethyl)aminophenyl)butyric acid
- 4-(p-N,N-Di-(beta-chloroethyl)aminophenyl)butyric acid
- 4-[4-[3-Chloro-1-(2-Chloroethyl)Propyl]Phenyl]Butanoic Acid
- 4-[Bis(2-Chloroethyl)Amino]Benzenebutanoic Acid
- 4-[Bis(2-chloroethyl)aminophenyl]butyric acid
- 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid
- 4-{4-[Bis(2-Chloroethyl)Amino]Phenyl}Butanoic Acid
- Ambochlorin
- Amboclorin
- Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
- Butanoic acid, 4-[bis(2-chloroethyl)amino]benzene
- Butyric acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]-
- Cb 1348
- Cb l348
- Chloraminophen
- Chloraminophene
- Chlorbutin
- Chloroambucil
- Chlorobutin
- Chlorobutine
- Clorambucilo
- Ecloril
- Elcoril
- Gamma-(P-Bis(2-Chloroethyl)Aminophenyl)Butyric Acid
- Leukeran
- Leukeran Tablets
- Leukersan
- Leukoran
- Linfolizin
- Linfolysin
- Lympholysin
- N,N-Di-(2-chloroethyl)-gamma-(p-aminophenyl)butyric acid
- Nci 3088
- Nsc 3088
- Phenylbutyric acid nitrogen mustard
- γ-[p-Bis(2-chloroethyl)aminophenyl]butyric acid
- See more synonyms
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Chlorambucil
CAS:Formula:C14H19Cl2NO2Purity:>98.0%(GC)(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:304.21CHLORAMBUCIL CRS
CAS:CHLORAMBUCIL CRSFormula:C14H19Cl2NO2Color and Shape:Added ModifiedMolecular weight:304.2122CHLORAMBUCIL FOR SYSTEM SUITABILITY CRS
CAS:CHLORAMBUCIL FOR SYSTEM SUITABILITY CRSFormula:C14H19Cl2NO2Color and Shape:PowderMolecular weight:304.2122Chlorambucil
CAS:ChlorambucilFormula:C14H19Cl2NO2Purity:99.4%Color and Shape:WhiteMolecular weight:303.07928CHLORAMBUCIL WITH IMPURITY G CRS
CAS:CHLORAMBUCIL WITH IMPURITY G CRSFormula:C14H19Cl2NO2Color and Shape:PowderMolecular weight:304.2122Chlorambucil
CAS:Aromatic amino-acids and their esters,other than those containing more than one kind of oxygen function for use as drugsFormula:C14H19Cl2NO2Color and Shape:White Off-White Granular Crystalline Powder NeedlesMolecular weight:303.07928Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Formula:C14H19Cl2NO2Purity:97.37% - 98.45%Color and Shape:Off-White Slightly Granular Powder Melting Point 65-69°CMolecular weight:304.21Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-
CAS:Formula:C14H19Cl2NO2Purity:95%Color and Shape:SolidMolecular weight:304.2122Chlorambucil
CAS:4-(4-(Bis(2-chloroethyl)amino)phenyl)butanoic acidFormula:C14H19Cl2NO2Purity:98%Molecular weight:304.21Chlorambucil
CAS:ChlorambucilFormula:C14H19Cl2NO2Purity:98%Color and Shape:Solid-PowderMolecular weight:304.21Chlorambucil, EP grade
CAS:Formula:C14H19Cl2NO2Purity:≤ 0.1% (HPLC)Color and Shape:White or almost white crystalline powderMolecular weight:304.21Chlorambucil
CAS:Formula:C14H19Cl2NO2Purity:≥ 98.0% (anhydrous)Color and Shape:White to off-white crystalline powderMolecular weight:304.21Chlorambucil-d8
CAS:Formula:C14H11D8Cl2NO2Color and Shape:White To Off-White SolidMolecular weight:312.26Chlorambucil
CAS:Formula:C14H19Cl2NO2Color and Shape:Pale Yellow To Off-White SolidMolecular weight:304.22Chlorambucil
CAS:Controlled ProductApplications Chlorambucil is a alkylating agent that is used as an chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cogia, A., et al.: Leuk. Lymph., 53, 1961 (2012); Tonino, S.H., et al.: Leuk. Lymph., 53, 1785 (2012); Smolej, L., et al.: Curr. Pharma. Design., 18, 3399 (2012);Formula:C14H19Cl2NO2Color and Shape:NeatMolecular weight:304.21Chlorambucil-d8
CAS:Controlled ProductFormula:C14D8H11Cl2NO2Color and Shape:NeatMolecular weight:312.262
![Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0030DZ.jpg&w=3840&q=75)
