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CAS 3052947-04-0

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    GRK2 degrader-1

    CAS:
    GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. It facilitates the degradation of GRK2 via the ubiquitin-proteasome pathway. In a pulmonary arterial hypertension (PAH) mouse model, GRK2 degrader-1 inhibits right ventricular remodeling and the increase in pulmonary arterial pressure. This compound is suitable for research in pulmonary arterial hypertension (PAH).
    Formula:C25H22N4O4S
    Molecular weight:474.54

    Ref: TM-TYD-05426

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