CAS 3055319-82-6

Formula: C25H30ClFN2O6S2

InChI: InChI=1S/C25H30ClFN2O6S2/c1-17(11-14-36(4,31)32)28-24(30)25(27)12-13-29(18(2)16-25)37(33,34)23-10-9-19(35-3)15-21(23)20-7-5-6-8-22(20)26/h5-11,14-15,17-18H,12-13,16H2,1-4H3,(H,28,30)/b14-11-/t17-,18-,25+/m1/s1

InChI key: YWSLDFWCZLZVST-DRZNZDJGSA-N

SMILES: C[C@@H]1C[C@@](CCN1S(=O)(=O)C2=C(C=C(C=C2)OC)C3=CC=CC=C3Cl)(C(=O)N[C@H](C)/C=C\S(=O)(=O)C)F

VVD-699

CAS: 3055319-82-6

VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.

Formula: C₂₅H₃₀ClFN₂O₆S₂

Color and Shape: Solid

Molecular weight: 573.097

Ref: TM-T206721